PMID- 17149751
OWN - NLM
STAT- MEDLINE
DCOM- 20070514
LR  - 20220408
IS  - 0360-4012 (Print)
IS  - 1097-4547 (Electronic)
IS  - 0360-4012 (Linking)
VI  - 85
IP  - 3
DP  - 2007 Feb 15
TI  - Mouse and rat BDNF gene structure and expression revisited.
PG  - 525-35
AB  - Brain-derived neurotrophic factor (BDNF) has important functions in the 
      development of the nervous system and in brain plasticity-related processes such 
      as memory, learning, and drug addiction. Despite the fact that the function and 
      regulation of rodent BDNF gene expression have received close attention during 
      the last decade, knowledge of the structural organization of mouse and rat BDNF 
      gene has remained incomplete. We have identified and characterized several mouse 
      and rat BDNF transcripts containing novel 5' untranslated exons and introduced a 
      new numbering system for mouse and rat BDNF exons. According to our results both 
      mouse and rat BDNF gene consist of eight 5' untranslated exons and one protein 
      coding 3' exon. Transcription of the gene results in BDNF transcripts containing 
      one of the eight 5' exons spliced to the protein coding exon and in a transcript 
      containing only 5' extended protein coding exon. We also report the distinct 
      tissue-specific expression profiles of each of the mouse and rat 5' exon-specific 
      transcripts in different brain regions and nonneural tissues. In addition, we 
      show that kainic acid-induced seizures that lead to changes in cellular Ca(2+) 
      levels as well as inhibition of DNA methylation and histone deacetylation 
      contribute to the differential regulation of the expression of BDNF transcripts. 
      Finally, we confirm that mouse and rat BDNF gene loci do not encode antisense 
      mRNA transcripts, suggesting that mechanisms of regulation for rodent and human 
      BDNF genes differ substantially.
FAU - Aid, Tamara
AU  - Aid T
AD  - Department of Gene Technology, Tallinn University of Technology, Tallinn, 
      Estonia.
FAU - Kazantseva, Anna
AU  - Kazantseva A
FAU - Piirsoo, Marko
AU  - Piirsoo M
FAU - Palm, Kaia
AU  - Palm K
FAU - Timmusk, Tonis
AU  - Timmusk T
LA  - eng
SI  - GENBANK/EF125669
SI  - GENBANK/EF125670
SI  - GENBANK/EF125671
SI  - GENBANK/EF125672
SI  - GENBANK/EF125673
SI  - GENBANK/EF125674
SI  - GENBANK/EF125675
SI  - GENBANK/EF125676
SI  - GENBANK/EF125677
SI  - GENBANK/EF125678
SI  - GENBANK/EF125679
SI  - GENBANK/EF125680
SI  - GENBANK/EF125681
SI  - GENBANK/EF125682
SI  - GENBANK/EF125683
SI  - GENBANK/EF125684
SI  - GENBANK/EF125685
SI  - GENBANK/EF125686
SI  - GENBANK/EF125687
SI  - GENBANK/EF125688
SI  - GENBANK/EF125689
SI  - GENBANK/EF125690
GR  - 067952/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Brain/physiology
MH  - Brain-Derived Neurotrophic Factor/*chemistry/*genetics
MH  - DNA Methylation
MH  - Exons
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Transcription, Genetic
PMC - PMC1878509
MID - UKMS543
OID - NLM: UKMS543
EDAT- 2006/12/07 09:00
MHDA- 2007/05/15 09:00
PMCR- 2009/05/16
CRDT- 2006/12/07 09:00
PHST- 2006/12/07 09:00 [pubmed]
PHST- 2007/05/15 09:00 [medline]
PHST- 2006/12/07 09:00 [entrez]
PHST- 2009/05/16 00:00 [pmc-release]
AID - 10.1002/jnr.21139 [doi]
PST - ppublish
SO  - J Neurosci Res. 2007 Feb 15;85(3):525-35. doi: 10.1002/jnr.21139.