PMID- 17150017
OWN - NLM
STAT- MEDLINE
DCOM- 20070108
LR  - 20191026
IS  - 1744-7682 (Electronic)
IS  - 1471-2598 (Linking)
VI  - 7
IP  - 1
DP  - 2007 Jan
TI  - Interleukin-18 as a potential therapeutic target in chronic 
      autoimmune/inflammatory conditions.
PG  - 31-40
AB  - Interleukin-18 (IL-18), a recently identified immunoregulatory and inflammatory 
      cytokine, has attracted a profound interest as a potential therapeutic target in 
      autoimmune/inflammatory disorders. In this review the authors focus on: IL-18 
      biology as an important link between innate and adaptive immunity; evidence of 
      its pro-inflammatory role in several human autoimmune and chronic inflammatory 
      disorders; and data indicating that IL-18 blockade in animal models results in 
      prevention/amelioration of the disease process and preservation of the target 
      tissue integrity and function. Finally, the authors analyse strategies presently 
      under development to block IL-18 function and potential pitfalls resulting from 
      IL-18 blockade that should be considered in ongoing/future clinical trials.
FAU - Bombardieri, Michele
AU  - Bombardieri M
AD  - Kings College London, Rheumatology Department, Guy's Hospital, St Thomas Street, 
      London, SE1 9RT, UK. michele.bombardieri@kcl.ac.uk
FAU - McInnes, Iain B
AU  - McInnes IB
FAU - Pitzalis, Costantino
AU  - Pitzalis C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
RN  - 0 (Immunologic Factors)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/genetics/*immunology/prevention & control
MH  - Chronic Disease
MH  - *Drug Delivery Systems/methods
MH  - Genetic Therapy/methods
MH  - Humans
MH  - Immunologic Factors/administration & dosage
MH  - Inflammation/genetics/immunology/prevention & control
MH  - Interleukin-18/*antagonists & inhibitors
RF  - 74
EDAT- 2006/12/08 09:00
MHDA- 2007/01/09 09:00
CRDT- 2006/12/08 09:00
PHST- 2006/12/08 09:00 [pubmed]
PHST- 2007/01/09 09:00 [medline]
PHST- 2006/12/08 09:00 [entrez]
AID - 10.1517/14712598.7.1.31 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2007 Jan;7(1):31-40. doi: 10.1517/14712598.7.1.31.