PMID- 17150271
OWN - NLM
STAT- MEDLINE
DCOM- 20070322
LR  - 20220311
IS  - 0167-8140 (Print)
IS  - 0167-8140 (Linking)
VI  - 82
IP  - 1
DP  - 2007 Jan
TI  - An analysis of 6-MV versus 18-MV photon energy plans for intensity-modulated 
      radiation therapy (IMRT) of lung cancer.
PG  - 55-62
AB  - PURPOSE: To analyse the supposed benefits of low over high photon energies for 
      the radiotherapy of lung cancer. MATERIALS AND METHODS: For 13 patients, 6- and 
      18-MV IMRT planning was performed using identical planning objectives and dose 
      constraints. Plans were compared according to dose-volume histogram (DVH) 
      analysis including conformity and homogeneity indices (CI and HI) and overall 
      plan quality (composite score CS), considering also magnitude and location of 
      planning target volumes (PTVs). RESULTS: With 6-MV plans, CSs were better in 
      11/13, HIs in 10/13 and CIs in 6/13 patients compared with 18-MV plans. Six-MV 
      plans resulted in a better normal tissue sparing except for specified dose levels 
      to the thorax and spinal cord. On average differences between 6 and 18 MV both 
      for the PTV and normal tissues were not statistically significant (p>0.05). 
      Considering size and location of the PTVs as well as their relative position to 
      normal tissue, overall no significant differences between 6 and 18 MV were 
      observed. CONCLUSIONS: On average no clinically or statistically significant 
      differences between 6- and 18-MV plans were observed. High photon energies should 
      therefore not be excluded a priori when a dose-calculation algorithm is utilized 
      that accurately accounts for heterogeneities.
FAU - Weiss, Elisabeth
AU  - Weiss E
AD  - Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 
      23298, USA. eweiss@mcvh-vcu.edu
FAU - Siebers, Jeffrey V
AU  - Siebers JV
FAU - Keall, Paul J
AU  - Keall PJ
LA  - eng
GR  - R01 CA093626/CA/NCI NIH HHS/United States
GR  - R01 CA 93626/CA/NCI NIH HHS/United States
GR  - R01 CA 98524/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20061205
PL  - Ireland
TA  - Radiother Oncol
JT  - Radiotherapy and oncology : journal of the European Society for Therapeutic 
      Radiology and Oncology
JID - 8407192
SB  - IM
MH  - Dose-Response Relationship, Radiation
MH  - Esophagus/radiation effects
MH  - Heart/radiation effects
MH  - Humans
MH  - Lung/radiation effects
MH  - Lung Neoplasms/*radiotherapy
MH  - *Photons
MH  - Radiotherapy/*methods
MH  - Radiotherapy Dosage
MH  - *Radiotherapy Planning, Computer-Assisted
MH  - Spinal Cord/radiation effects
EDAT- 2006/12/08 09:00
MHDA- 2007/03/23 09:00
CRDT- 2006/12/08 09:00
PHST- 2006/10/19 00:00 [received]
PHST- 2006/10/25 00:00 [accepted]
PHST- 2006/12/08 09:00 [pubmed]
PHST- 2007/03/23 09:00 [medline]
PHST- 2006/12/08 09:00 [entrez]
AID - S0167-8140(06)00562-7 [pii]
AID - 10.1016/j.radonc.2006.10.021 [doi]
PST - ppublish
SO  - Radiother Oncol. 2007 Jan;82(1):55-62. doi: 10.1016/j.radonc.2006.10.021. Epub 
      2006 Dec 5.