PMID- 17151862
OWN - NLM
STAT- MEDLINE
DCOM- 20070926
LR  - 20220410
IS  - 0012-186X (Print)
IS  - 0012-186X (Linking)
VI  - 50
IP  - 2
DP  - 2007 Feb
TI  - Brain-derived neurotrophic factor (BDNF) and type 2 diabetes.
PG  - 431-8
AB  - AIMS/HYPOTHESIS: Decreased levels of brain-derived neurotrophic factor (BDNF) 
      have been implicated in the pathogenesis of Alzheimer's disease and depression. 
      These disorders are associated with type 2 diabetes, and animal models suggest 
      that BDNF plays a role in insulin resistance. We therefore explored whether BDNF 
      plays a role in human glucose metabolism. SUBJECTS AND METHODS: We included 
      (Study 1) 233 humans divided into four groups depending on presence or absence of 
      type 2 diabetes and presence or absence of obesity; and (Study 2) seven healthy 
      volunteers who underwent both a hyperglycaemic and a 
      hyperinsulinaemic-euglycaemic clamp. RESULTS: Plasma levels of BDNF in Study 1 
      were decreased in humans with type 2 diabetes independently of obesity. Plasma 
      BDNF was inversely associated with fasting plasma glucose, but not with insulin. 
      No association was found between the BDNF G196A (Val66Met) polymorphism and 
      diabetes or obesity. In Study 2 an output of BDNF from the human brain was 
      detected at basal conditions. This output was inhibited when blood glucose levels 
      were elevated. In contrast, when plasma insulin was increased while maintaining 
      normal blood glucose, the cerebral output of BDNF was not inhibited, indicating 
      that high levels of glucose, but not insulin, inhibit the output of BDNF from the 
      human brain. CONCLUSIONS/INTERPRETATION: Low levels of BDNF accompany impaired 
      glucose metabolism. Decreased BDNF may be a pathogenetic factor involved not only 
      in dementia and depression, but also in type 2 diabetes, potentially explaining 
      the clustering of these conditions in epidemiological studies.
FAU - Krabbe, K S
AU  - Krabbe KS
AD  - The Centre of Inflammation and Metabolism, Department of Infectious Diseases, 
      Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. 
      karen.krabbe@dadlnet.dk
FAU - Nielsen, A R
AU  - Nielsen AR
FAU - Krogh-Madsen, R
AU  - Krogh-Madsen R
FAU - Plomgaard, P
AU  - Plomgaard P
FAU - Rasmussen, P
AU  - Rasmussen P
FAU - Erikstrup, C
AU  - Erikstrup C
FAU - Fischer, C P
AU  - Fischer CP
FAU - Lindegaard, B
AU  - Lindegaard B
FAU - Petersen, A M W
AU  - Petersen AM
FAU - Taudorf, S
AU  - Taudorf S
FAU - Secher, N H
AU  - Secher NH
FAU - Pilegaard, H
AU  - Pilegaard H
FAU - Bruunsgaard, H
AU  - Bruunsgaard H
FAU - Pedersen, B K
AU  - Pedersen BK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061207
PL  - Germany
TA  - Diabetologia
JT  - Diabetologia
JID - 0006777
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Insulin)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 9007-49-2 (DNA)
SB  - IM
CIN - Diabetologia. 2007 Aug;50(8):1781-2. PMID: 17546439
CIN - Diabetologia. 2007 Sep;50(9):2027-8; author reply 2029-30. PMID: 17634920
MH  - Adult
MH  - Blood Glucose/drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/blood/genetics/*physiology
MH  - C-Reactive Protein/metabolism
MH  - Cardiovascular Diseases/blood
MH  - Cross-Sectional Studies
MH  - DNA/genetics/isolation & purification
MH  - Diabetes Mellitus, Type 2/*blood/epidemiology/genetics
MH  - Diabetic Angiopathies/blood
MH  - Glucose Clamp Technique
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/pharmacology
MH  - Insulin Resistance
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide
MH  - Reference Values
EDAT- 2006/12/08 09:00
MHDA- 2007/09/27 09:00
CRDT- 2006/12/08 09:00
PHST- 2006/06/27 00:00 [received]
PHST- 2006/10/19 00:00 [accepted]
PHST- 2006/12/08 09:00 [pubmed]
PHST- 2007/09/27 09:00 [medline]
PHST- 2006/12/08 09:00 [entrez]
AID - 10.1007/s00125-006-0537-4 [doi]
PST - ppublish
SO  - Diabetologia. 2007 Feb;50(2):431-8. doi: 10.1007/s00125-006-0537-4. Epub 2006 Dec 
      7.