PMID- 17152443
OWN - NLM
STAT- MEDLINE
DCOM- 20070104
LR  - 20191003
IS  - 0018-9294 (Print)
IS  - 1558-2531 (Electronic)
IS  - 0018-9294 (Linking)
VI  - 53
IP  - 12 Pt 2
DP  - 2006 Dec
TI  - Relaxation-based multichannel signal combination (RELAX-MUSIC) for ROC analysis 
      of percept-related neuronal activity.
PG  - 2615-8
AB  - In this letter, we consider how to combine neuronal signals from multiple 
      electrodes to optimally predict behavioral choices from observed neural activity. 
      The predictability is often quantified by the area under the receiver operating 
      characteristic (ROC) curve, also called choice probability (CP) in 
      neurophysiology. We exploit a distribution-free relaxation based multichannel 
      signal combination (RELAX-MUSIC) approach that requires only simple pairwise 
      combination and recursive implementation for optimizing the area under the ROC 
      curve. A permutation test is employed to assess the statistical significance of 
      the derived CP. We demonstrate that the RELAX-MUSIC approach outperforms the 
      commonly used response pooling and Fisher linear discriminant (FLD) methods. The 
      excellent performances of the RELAX-MUSIC approach for predicting perceptual 
      decisions from neural activity are demonstrated via examples using simulated and 
      experimental data.
FAU - Wang, Zhisong
AU  - Wang Z
AD  - School of Health Information Sciences, University of Texas Health Science Center 
      at Houston, Houston, TX 77030, USA.
FAU - Maier, Alexander
AU  - Maier A
FAU - Leopold, David A
AU  - Leopold DA
FAU - Liang, Hualou
AU  - Liang H
LA  - eng
GR  - R01 NS054314/NS/NINDS NIH HHS/United States
GR  - R03 MH067776/MH/NIMH NIH HHS/United States
GR  - ZIA MH002838-06/Intramural NIH HHS/United States
GR  - R01 MH072034/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - IEEE Trans Biomed Eng
JT  - IEEE transactions on bio-medical engineering
JID - 0012737
SB  - IM
MH  - Action Potentials/*physiology
MH  - Algorithms
MH  - Animals
MH  - Cerebral Cortex/*physiology
MH  - Choice Behavior/*physiology
MH  - Electroencephalography/*methods
MH  - Evoked Potentials/*physiology
MH  - Macaca
MH  - *ROC Curve
MH  - Signal Processing, Computer-Assisted
MH  - Visual Perception/*physiology
PMC - PMC3429334
MID - NIHMS398163
EDAT- 2006/12/13 09:00
MHDA- 2007/01/05 09:00
PMCR- 2012/08/28
CRDT- 2006/12/13 09:00
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2007/01/05 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
PHST- 2012/08/28 00:00 [pmc-release]
AID - 10.1109/TBME.2006.886605 [doi]
PST - ppublish
SO  - IEEE Trans Biomed Eng. 2006 Dec;53(12 Pt 2):2615-8. doi: 
      10.1109/TBME.2006.886605.