PMID- 17154346
OWN - NLM
STAT- MEDLINE
DCOM- 20070809
LR  - 20220408
IS  - 1053-8569 (Print)
IS  - 1053-8569 (Linking)
VI  - 16
IP  - 6
DP  - 2007 Jun
TI  - Hospitalisations and emergency department visits due to drug-drug interactions: a 
      literature review.
PG  - 641-51
AB  - PURPOSE: Our objective was to evaluate the incidence of adverse patient outcomes 
      due to drug-drug interactions (D-DIs), the type of drugs involved and the 
      underlying reason. As a proxy for adverse patient outcomes, emergency department 
      (ED) visits, hospital admissions and re-hospitalisations were assessed. METHODS: 
      A literature search in the Medline and Embase database (1990-2006) was performed 
      and references were tracked. An overall cumulative incidence was estimated by 
      dividing the sum of the cases by the sum of the study populations. RESULTS: 
      Twenty-three studies were found assessing the relationship between D-DIs and 
      ED-visits, hospitalisations or re-hospitalisations. The studies with a large 
      study size showed low incidences and vice versa. D-DIs were held responsible for 
      0.054% of the ED-visits, 0.57% of the hospital admissions and 0.12% of the 
      re-hospitalisations. In the elderly population, D-DIs were held responsible for 
      4.8% of the admissions. Drugs most often involved were NSAIDs and cardiovascular 
      drugs. The reasons for admissions or ED-visits, which were most often found were 
      GI-tract bleeding, hyper- or hypotension and cardiac rhythm disturbances. 
      CONCLUSION: This review provides information on the overall incidence of D-DIs as 
      a cause of adverse patient outcomes, although there is still uncertainty about 
      the impact of D-DIs on adverse patient outcomes. Our results suggest that a 
      limited number of drugs are involved in the majority of cases and that the number 
      of reasons for admission as a consequence of D-DIs seems to be modest.
CI  - Copyright (c) 2006 John Wiley & Sons, Ltd.
FAU - Becker, Matthijs L
AU  - Becker ML
AD  - Pharmaco-epidemiology Unit, Department of Epidemiology & Biostatistics, Erasmus 
      Medical Center, Rotterdam, The Netherlands.
FAU - Kallewaard, Marjon
AU  - Kallewaard M
FAU - Caspers, Peter W J
AU  - Caspers PW
FAU - Visser, Loes E
AU  - Visser LE
FAU - Leufkens, Hubert G M
AU  - Leufkens HG
FAU - Stricker, Bruno H Ch
AU  - Stricker BH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Pharmacoepidemiol Drug Saf
JT  - Pharmacoepidemiology and drug safety
JID - 9208369
SB  - IM
MH  - *Drug Interactions
MH  - *Emergency Service, Hospital
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
RF  - 37
EDAT- 2006/12/13 09:00
MHDA- 2007/08/10 09:00
CRDT- 2006/12/13 09:00
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2007/08/10 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
AID - 10.1002/pds.1351 [doi]
PST - ppublish
SO  - Pharmacoepidemiol Drug Saf. 2007 Jun;16(6):641-51. doi: 10.1002/pds.1351.