PMID- 17154368
OWN - NLM
STAT- MEDLINE
DCOM- 20070501
LR  - 20101118
IS  - 0022-3549 (Print)
IS  - 0022-3549 (Linking)
VI  - 96
IP  - 3
DP  - 2007 Mar
TI  - Temperature and pH sensitive hydrogels: an approach towards smart semen-triggered 
      vaginal microbicidal vehicles.
PG  - 670-81
AB  - Microbicides are drug delivery systems (DDSs) for the prevention of sexual 
      transmission of HIV and other STDs. A topically applied vaginal microbicidal gel 
      should provide uniform coating of vaginal tissue, retention of this gel layer 
      prior to intercourse, and controlled release kinetics of antivirals to inactivate 
      the viral load potentially introduced during sexual activity. Here, we describe 
      the microbicide-oriented characterization of a DDS made with a dual pH sensitive 
      and thermosensitive smart polymer gel composed of a random terpolymer of 
      N-isopropyl acrylamide, butyl methacrylate, and acrylic acid. The system was 
      engineered to coat vaginal tissue with a stable gel layer and to release 
      entrapped model agents in a burst release profile in response to the presence of 
      the infecting agent: semen. The gel rheology, layer erosion properties, model 
      drug release kinetics, and cytocompatibility of the terpolymer system were 
      studied. Negligible erosion of the gel in the presence of vaginal fluid simulant 
      suggests prolonged retention. Burst release of molecular and macromolecular model 
      compounds was observed when the system's pH changed from the vaginal pH to the pH 
      of semen, and cytotoxicity studies showed that the terpolymer is equally 
      cytocompatible as a commonly used polymeric vaginal carrier.
CI  - 2006 Wiley-Liss, Inc. and the American Pharmacists Association
FAU - Gupta, Kavita M
AU  - Gupta KM
AD  - Department of Bioengineering, University of Utah, Biopolymers Research Building, 
      20 S. 2030 E. Salt Lake City, Utah 84112, USA.
FAU - Barnes, Scott R
AU  - Barnes SR
FAU - Tangaro, Rachel A
AU  - Tangaro RA
FAU - Roberts, Meredith C
AU  - Roberts MC
FAU - Owen, Derek H
AU  - Owen DH
FAU - Katz, David F
AU  - Katz DF
FAU - Kiser, Patrick F
AU  - Kiser PF
LA  - eng
GR  - R01-AI48103/AI/NIAID NIH HHS/United States
GR  - R21-AI062445/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Pharm Sci
JT  - Journal of pharmaceutical sciences
JID - 2985195R
RN  - 0 (Anti-Infective Agents, Local)
RN  - 0 (Hydrogels)
RN  - 0 (Pharmaceutical Vehicles)
SB  - IM
EIN - J Pharm Sci. 2009 Mar;98(3):1198
MH  - Administration, Intravaginal
MH  - Anti-Infective Agents, Local/*administration & dosage/chemistry/pharmacology
MH  - Chemistry, Pharmaceutical
MH  - *Drug Delivery Systems
MH  - Female
MH  - HIV Infections/*prevention & control/transmission
MH  - Humans
MH  - Hydrogels
MH  - Hydrogen-Ion Concentration
MH  - Male
MH  - Pharmaceutical Vehicles
MH  - Semen/*metabolism
MH  - Solubility
MH  - Temperature
MH  - Vagina/*metabolism
MH  - Viscosity
EDAT- 2006/12/13 09:00
MHDA- 2007/05/02 09:00
CRDT- 2006/12/13 09:00
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2007/05/02 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
AID - S0022-3549(16)32201-8 [pii]
AID - 10.1002/jps.20752 [doi]
PST - ppublish
SO  - J Pharm Sci. 2007 Mar;96(3):670-81. doi: 10.1002/jps.20752.