PMID- 17154468
OWN - NLM
STAT- MEDLINE
DCOM- 20070220
LR  - 20171116
IS  - 1525-7797 (Print)
IS  - 1525-7797 (Linking)
VI  - 7
IP  - 12
DP  - 2006 Dec
TI  - Amphiphilic model conetworks based on cross-linked star copolymers of benzyl 
      methacrylate and 2-(dimethylamino)ethyl methacrylate: synthesis, 
      characterization, and DNA adsorption studies.
PG  - 3396-405
AB  - Six amphiphilic model conetworks of a new structure, that of cross-linked 
      "in-out" star copolymers, were synthesized by the group transfer polymerization 
      (GTP) of the hydrophobic monomer benzyl methacrylate (BzMA) and the ionizable 
      hydrophilic monomer 2-(dimethylamino)ethyl methacrylate (DMAEMA) in a one-pot 
      preparation. The synthesis took place in tetrahydrofuran (THF) using 
      tetrabutylammonium bibenzoate (TBABB) as the catalyst, 
      1-methoxy-1-(trimethylsiloxy)-2-methyl-propene (MTS) as the initiator, and 
      ethylene glycol dimethacrylate (EGDMA) as the cross-linker. Three heteroarm 
      star-, two star block-, one statistical copolymer star-, and one homopolymer 
      star-based networks were prepared. The synthesis of these star-based networks 
      involved four to six steps, including the preparation of the linear (co)polymers, 
      the "arm-first" and the "in-out" star copolymers, and finally the network. The 
      precursors and the extractables were characterized using gel permeation 
      chromatography (GPC) and proton nuclear magnetic resonance (1H NMR) spectroscopy. 
      The degrees of swelling (DSs) of all the networks were measured in THF, while the 
      aqueous DSs were measured as a function of pH. The DSs at low pH were higher than 
      those at neutral or high pH because of the protonation of the DMAEMA units and 
      were found to be dependent on the structure of the network. The DSs in THF were 
      higher than those in neutral water and were independent of the structure. 
      Finally, DNA adsorption studies onto the networks indicated that the DNA binding 
      was governed by electrostatics.
FAU - Achilleos, Demetra S
AU  - Achilleos DS
AD  - Department of Chemistry, University of Cyprus, P. O. Box 20537, 1678 Nicosia, 
      Cyprus.
FAU - Georgiou, Theoni K
AU  - Georgiou TK
FAU - Patrickios, Costas S
AU  - Patrickios CS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biomacromolecules
JT  - Biomacromolecules
JID - 100892849
RN  - 0 (Furans)
RN  - 0 (Indicators and Reagents)
RN  - 0 (Methacrylates)
RN  - 3N8FZZ6PY4 (tetrahydrofuran)
RN  - 9007-49-2 (DNA)
RN  - O0V97PV2G1 (2-(dimethylamino)ethyl methacrylate)
RN  - Z3248K2SSM (benzyl methacrylate)
SB  - IM
MH  - Adsorption
MH  - DNA/*chemistry
MH  - Furans
MH  - Hydrogen-Ion Concentration
MH  - Indicators and Reagents
MH  - Methacrylates/chemical synthesis/*chemistry
MH  - Models, Molecular
MH  - Molecular Conformation
EDAT- 2006/12/13 09:00
MHDA- 2007/02/21 09:00
CRDT- 2006/12/13 09:00
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2007/02/21 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
AID - 10.1021/bm060699m [doi]
PST - ppublish
SO  - Biomacromolecules. 2006 Dec;7(12):3396-405. doi: 10.1021/bm060699m.