PMID- 17156650
OWN - NLM
STAT- MEDLINE
DCOM- 20080424
LR  - 20181201
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 86
IP  - 34
DP  - 2006 Sep 12
TI  - [Inhibitory effect of irbesartan on restenosis after balloon angioplasty and 
      mechanism thereof: experiment with rabbits].
PG  - 2395-8
AB  - OBJECTIVE: To investigate the inhibitory effect of irbesartan on the restenosis 
      after balloon angioplasty and mechanism thereof. METHODS: Forty-eight Harbin 
      white rabbits underwent balloon angioplasty at the left common carotid artery to 
      establish models of restenosis (RS) and then were randomly divided into 3 groups 
      of 8 rabbits: 7 d, 14 d, and 28 d to be fed with the diet with 35 mg/kg 
      irbesartan till the day when the rabbits were to be killed, each group with 4 
      controls fed with normal diet At the scheduled days the rabbits were killed and 
      their left common carotid arteries, livers, and kidneys were taken out to undergo 
      morphological examination. The areas of the tunica intima, tunica media, and 
      lumen of the common carotid artery were measured. Immunohistochemistry was used 
      to detect the nuclear factor-kappaB p65 (NF-kappaB p65) and proliferating cell 
      nuclear antigen (PCNA) protein. RT-PCR was used to detect the mRNA expression of 
      inhibitor-kappaB (I-kappaB) and monocyte chemoattractant protein-1 (MCP-1). 
      RESULTS: No abnormality was found in the specimens of liver and kidney. 
      Measurement showed that the area of tunica intima of the 7 d irbesartan group was 
      0.34 mm(2) +/- 0.15 mm(2), significantly smaller than that of the controls (1.05 
      mm(2) +/- 0.38 mm(2), P < 0.05), and the area of arterial lumen of the 28 d group 
      was 4.25 mm(2) +/- 0.29 mm(2), significantly larger than that of the controls 
      (2.56 mm(2) +/- 1.02 mm(2), P < 0.05). Immunohistochemistry showed that the rates 
      of NF-kappaB p65 positive cell and PCNA positive cell of the 7 d irbesartan group 
      were both significantly lower than those of the controls (both P < 0.05). The 
      mRNA expression of I-kappaB in the vascular wall of the 7 d irbesartan group was 
      significantly lower than that of the controls. The mRNA expression levels of 
      MCP-1 at different time points were all significantly lower than those of the 
      corresponding controls (all P < 0.05). CONCLUSION: Irbesartan inhibits the RS 
      after injury of arterial wall by balloon angioplasty via suppressing the 
      activation of NF-kappaB p65 which controls the expression of I-kappaB and MCP-1.
FAU - Wang, Jia-hong
AU  - Wang JH
AD  - Department of Cardiology, First Affiliated Hospital of Harbin Medical University, 
      Harbin, China.
FAU - Huang, Yong-lin
AU  - Huang YL
FAU - Zhao, Min
AU  - Zhao M
FAU - Cao, Feng-lin
AU  - Cao FL
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Chemokine CCL2)
RN  - 0 (I-kappa B Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Proliferating Cell Nuclear Antigen)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tetrazoles)
RN  - J0E2756Z7N (Irbesartan)
SB  - IM
MH  - Animals
MH  - Biphenyl Compounds/*therapeutic use
MH  - Carotid Artery, Common/drug effects/metabolism/pathology
MH  - Chemokine CCL2/genetics
MH  - Coronary Restenosis/*drug therapy/metabolism
MH  - Gene Expression
MH  - I-kappa B Proteins/genetics
MH  - Immunohistochemistry
MH  - Irbesartan
MH  - Male
MH  - NF-kappa B/biosynthesis
MH  - Proliferating Cell Nuclear Antigen/analysis
MH  - RNA, Messenger/genetics/metabolism
MH  - Rabbits
MH  - Random Allocation
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tetrazoles/*therapeutic use
EDAT- 2006/12/13 09:00
MHDA- 2008/04/25 09:00
CRDT- 2006/12/13 09:00
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2008/04/25 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2006 Sep 12;86(34):2395-8.