PMID- 17159100
OWN - NLM
STAT- MEDLINE
DCOM- 20070108
LR  - 20220408
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 67
IP  - 11
DP  - 2006 Dec 12
TI  - Body mass index and the risk of Parkinson disease.
PG  - 1955-9
AB  - OBJECTIVE: To examine the association between body mass index (BMI) and the risk 
      of Parkinson disease (PD). METHODS: Study cohorts included 22,367 Finnish men and 
      23,439 women 25 to 59 years of age without a history of PD at baseline. Hazards 
      ratios (HRs) of incident PD were estimated for different levels of BMI. RESULTS: 
      During a mean follow-up period of 18.8 years, 272 men and 254 women developed 
      incident PD. After adjustment for confounding factors (age, study years, systolic 
      blood pressure, total cholesterol, education, leisure-time physical activity, 
      smoking, and alcohol, coffee, and tea consumption), the HRs of PD at different 
      levels of BMI (<23, 23 to 24.9, 25 to 26.9, 27 to 29.9, and > or =30 kg/m(2)) 
      were 1.00, 1.97 (95% CI: 1.21 to 3.22), 1.83 (95% CI: 1.12 to 2.99), 2.34 (95% 
      CI: 1.45 to 3.78), and 2.44 (95% CI: 1.44 to 4.15) in men, and 1.00, 1.50 (95% 
      CI: 0.95 to 2.37), 1.65 (95% CI: 1.05 to 2.59), 1.79 (95% CI: 1.15 to 2.80), and 
      1.77 (95% CI: 1.12 to 2.78) in women, and 1.00, 1.70 (95% CI: 1.23 to 2.37), 1.70 
      (95% CI: 1.23 to 2.37), 2.02 (95% CI: 1.46 to 2.79), and 2.03 (95% CI: 1.44 to 
      2.85) in men and women combined (adjusted also for sex). In both sexes combined, 
      the multivariate-adjusted direct association between BMI and the risk of PD was 
      present both in subjects aged 25 to 49 years and 50 to 59 years, in never smokers 
      and smokers and in participants diagnosed PD before and after 65 years of age. 
      CONCLUSION: Body mass index is associated with a risk of Parkinson disease. The 
      effect is graded and independent of other risk factors.
FAU - Hu, G
AU  - Hu G
AD  - Department of Epidemiology and Health Promotion, National Public Health 
      Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland. hu.gang@ktl.fi
FAU - Jousilahti, P
AU  - Jousilahti P
FAU - Nissinen, A
AU  - Nissinen A
FAU - Antikainen, R
AU  - Antikainen R
FAU - Kivipelto, M
AU  - Kivipelto M
FAU - Tuomilehto, J
AU  - Tuomilehto J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
CIN - Neurology. 2007 Jun 12;68(24):2156; author reply 2156-7. PMID: 17562841
MH  - Adult
MH  - Age Factors
MH  - *Body Mass Index
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/epidemiology/physiopathology
MH  - Parkinson Disease/diagnosis/*epidemiology/physiopathology
MH  - Prospective Studies
MH  - Risk Factors
MH  - Sex Factors
EDAT- 2006/12/13 09:00
MHDA- 2007/01/09 09:00
CRDT- 2006/12/13 09:00
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2007/01/09 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
AID - 67/11/1955 [pii]
AID - 10.1212/01.wnl.0000247052.18422.e5 [doi]
PST - ppublish
SO  - Neurology. 2006 Dec 12;67(11):1955-9. doi: 10.1212/01.wnl.0000247052.18422.e5.