PMID- 17159149
OWN - NLM
STAT- MEDLINE
DCOM- 20070302
LR  - 20181113
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 103
IP  - 51
DP  - 2006 Dec 19
TI  - Delay of T cell senescence by caloric restriction in aged long-lived nonhuman 
      primates.
PG  - 19448-53
AB  - Caloric restriction (CR) has long been known to increase median and maximal 
      lifespans and to decreases mortality and morbidity in short-lived animal models, 
      likely by altering fundamental biological processes that regulate aging and 
      longevity. In rodents, CR was reported to delay the aging of the immune system 
      (immune senescence), which is believed to be largely responsible for a dramatic 
      increase in age-related susceptibility to infectious diseases. However, it is 
      unclear whether CR can exert similar effects in long-lived organisms. Previous 
      studies involving 2- to 4-year CR treatment of long-lived primates failed to find 
      a CR effect or reported effects on the immune system opposite to those seen in 
      CR-treated rodents. Here we show that long-term CR delays the adverse effects of 
      aging on nonhuman primate T cells. CR effected a marked improvement in the 
      maintenance and/or production of naive T cells and the consequent preservation of 
      T cell receptor repertoire diversity. Furthermore, CR also improved T cell 
      function and reduced production of inflammatory cytokines by memory T cells. Our 
      results provide evidence that CR can delay immune senescence in nonhuman 
      primates, potentially contributing to an extended lifespan by reducing 
      susceptibility to infectious disease.
FAU - Messaoudi, Ilhem
AU  - Messaoudi I
AD  - Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, 
      Oregon Health and Science University, Beaverton, OR 97006, USA.
FAU - Warner, Jessica
AU  - Warner J
FAU - Fischer, Miranda
AU  - Fischer M
FAU - Park, Buyng
AU  - Park B
FAU - Hill, Brenna
AU  - Hill B
FAU - Mattison, Julie
AU  - Mattison J
FAU - Lane, Mark A
AU  - Lane MA
FAU - Roth, George S
AU  - Roth GS
FAU - Ingram, Donald K
AU  - Ingram DK
FAU - Picker, Louis J
AU  - Picker LJ
FAU - Douek, Daniel C
AU  - Douek DC
FAU - Mori, Motomi
AU  - Mori M
FAU - Nikolich-Zugich, Janko
AU  - Nikolich-Zugich J
LA  - eng
GR  - AG21384/AG/NIA NIH HHS/United States
GR  - P51 RR000163/RR/NCRR NIH HHS/United States
GR  - U01 AG021384/AG/NIA NIH HHS/United States
GR  - T32 AI007472/AI/NIAID NIH HHS/United States
GR  - Intramural NIH HHS/United States
GR  - K01 RR000163/RR/NCRR NIH HHS/United States
GR  - RR0163/RR/NCRR NIH HHS/United States
GR  - 5T32 AI0077472-10/AI/NIAID NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20061211
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - *Caloric Restriction
MH  - Cell Count
MH  - Cellular Senescence/immunology/*physiology
MH  - Cytokines/metabolism
MH  - Flow Cytometry
MH  - Macaca mulatta
MH  - Receptors, Antigen, T-Cell/metabolism
MH  - T-Lymphocytes/immunology/*physiology
PMC - PMC1748246
COIS- The authors declare no conflict of interest.
EDAT- 2006/12/13 09:00
MHDA- 2007/03/03 09:00
PMCR- 2007/06/19
CRDT- 2006/12/13 09:00
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2007/03/03 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
PHST- 2007/06/19 00:00 [pmc-release]
AID - 0606661103 [pii]
AID - 4377 [pii]
AID - 10.1073/pnas.0606661103 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19448-53. doi: 
      10.1073/pnas.0606661103. Epub 2006 Dec 11.