PMID- 17159619
OWN - NLM
STAT- MEDLINE
DCOM- 20070308
LR  - 20181113
IS  - 1543-3633 (Print)
IS  - 1543-3641 (Electronic)
IS  - 1543-3633 (Linking)
VI  - 19
IP  - 4
DP  - 2006 Dec
TI  - Markers of macrophage activation and axonal injury are associated with 
      prospective memory in HIV-1 disease.
PG  - 217-21
AB  - OBJECTIVE: To use clinical specimens to better understand the neuropathogenesis 
      of prospective memory (ProM) functioning in persons with HIV-1 infection. 
      BACKGROUND: Emergent evidence suggests that HIV-1 is associated with impaired 
      ProM, but the underlying neuropathophysiology of this deficit is not known. 
      METHODS: Thirty-five nondemented subjects with HIV-1 infection completed measures 
      of both ProM (ie, memory for future intentions) and retrospective memory (RM; ie, 
      memory for past episodes). A panel of biomarkers reflecting several possible 
      neuropathogenic mechanisms of HIV was measured in plasma and cerebrospinal fluid, 
      including HIV-1 RNA, total tau, monocyte chemoattractant protein-1 (MCP-1), 
      soluble receptor for tumor necrosis factor type II, and fibroblast growth factor 
      1. RESULTS: After controlling for antiretroviral therapy and CD4 lymphocyte 
      count, higher levels of MCP-1 in plasma, and soluble receptor for tumor necrosis 
      factor type II and tau in cerebrospinal fluid were associated with ProM, but not 
      RM. Markers of astrocytosis, growth factor depletion, and HIV-1 replication did 
      not predict either ProM or RM. CONCLUSIONS: ProM impairment in HIV-1 may be 
      dissociable from RM, perhaps reflecting specific neuropathogenic mechanisms of 
      macrophage activation and axonal injury.
FAU - Woods, Steven Paul
AU  - Woods SP
AD  - Department of Psychiatry, School of Medicine, University of California, San 
      Diego, La Jolla, CA 92093, USA. spwoods@ucsd.edu
FAU - Morgan, Erin E
AU  - Morgan EE
FAU - Marquie-Beck, Jennifer
AU  - Marquie-Beck J
FAU - Carey, Catherine L
AU  - Carey CL
FAU - Grant, Igor
AU  - Grant I
FAU - Letendre, Scott L
AU  - Letendre SL
CN  - HIV Neurobehavioral Research Center (HNRC) Group
LA  - eng
GR  - P30 MH062512/MH/NIMH NIH HHS/United States
GR  - R01 MH073419/MH/NIMH NIH HHS/United States
GR  - MH62512/MH/NIMH NIH HHS/United States
GR  - MH73419/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Cogn Behav Neurol
JT  - Cognitive and behavioral neurology : official journal of the Society for 
      Behavioral and Cognitive Neurology
JID - 101167278
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Immunoglobulin G)
RN  - 0 (RNA, Viral)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (tau Proteins)
RN  - 104781-85-3 (Fibroblast Growth Factor 1)
RN  - OP401G7OJC (Etanercept)
SB  - IM
MH  - Adult
MH  - Axons/immunology/*pathology
MH  - Biomarkers/blood/cerebrospinal fluid
MH  - Chemokine CCL2/blood/cerebrospinal fluid
MH  - Etanercept
MH  - Female
MH  - Fibroblast Growth Factor 1/blood/cerebrospinal fluid
MH  - HIV Infections/complications/*immunology
MH  - HIV-1/genetics/immunology
MH  - Humans
MH  - Immunoglobulin G/blood/cerebrospinal fluid
MH  - Macrophages/immunology/*metabolism
MH  - Male
MH  - Memory/*physiology
MH  - Memory Disorders/complications/diagnosis/*immunology
MH  - Middle Aged
MH  - RNA, Viral/blood/cerebrospinal fluid
MH  - Receptors, Tumor Necrosis Factor/blood
MH  - Statistics, Nonparametric
MH  - tau Proteins/blood/cerebrospinal fluid
PMC - PMC1939824
MID - NIHMS19762
COIS- The authors have reported no conflicts of interest.
EDAT- 2006/12/13 09:00
MHDA- 2007/03/09 09:00
PMCR- 2007/08/03
CRDT- 2006/12/13 09:00
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2007/03/09 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
PHST- 2007/08/03 00:00 [pmc-release]
AID - 00146965-200612000-00009 [pii]
AID - 10.1097/01.wnn.0000213916.10514.57 [doi]
PST - ppublish
SO  - Cogn Behav Neurol. 2006 Dec;19(4):217-21. doi: 
      10.1097/01.wnn.0000213916.10514.57.