PMID- 17160088
OWN - NLM
STAT- MEDLINE
DCOM- 20071219
LR  - 20220408
IS  - 0307-0565 (Print)
IS  - 0307-0565 (Linking)
VI  - 31
IP  - 7
DP  - 2007 Jul
TI  - The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin 
      levels in a middle-aged Austrian population.
PG  - 1099-103
AB  - CONTEXT: The sterol regulatory element-binding protein-1c (SREBP-1c) is a 
      transcription factor involved in the regulation of lipid and glucose metabolism 
      and has been implicated in the pathophysiology of type 2 diabetes mellitus 
      (T2DM). OBJECTIVE: We aimed to confirm associations of the SREBF-1 gene with T2DM 
      in an Austrian population and to study possible associations with 
      diabetes-related quantitative traits. DESIGN, SETTINGS AND PARTICIPANTS: We 
      genotyped a diabetic cohort (n=446) along with a control group (n=1524) for a 
      common C/G variation that is located in exon 18c (rs2297508) and has been 
      associated with obesity and T2DM in French populations. MAIN OUTCOME MEASURES: 
      Body mass index (BMI), indices of insulin sensitivity and beta-cell function, 
      plasma adiponectin, T2DM and single-nucleotide polymorphism rs2297508. RESULTS: 
      Genotype distributions associated with rs2297508 differed by T2DM status 
      (P=0.0045), but not by BMI. The variant G allele was associated with a modest, 
      but significant, increase in the prevalence of T2DM after adjustment for age, sex 
      and BMI (G/G: odds ratios (OR) (95% confidence intervals)=1.45 (0.99-2.11) and 
      G/C: OR=1.37 (1.04-1.81)). In a cross-sectional population of non-diabetic 
      subjects, associations of rs2297508 genotypes with plasma adiponectin levels 
      adjusted for age, sex and BMI (P=0.0017) were observed in that the risk G/G 
      genotype displayed the lowest adiponectin levels. CONCLUSIONS: We observed 
      associations of rs2297508 with T2DM prevalence and plasma adiponectin. SREBP-1c 
      has been implicated in the regulation of adiponectin gene expression. Our results 
      therefore raise the possibility that sequence variations at the SREBF-1 gene 
      locus might contribute to T2DM risk, at least in part, by altering circulating 
      adiponectin levels.
FAU - Felder, T K
AU  - Felder TK
AD  - Department of Laboratory Medicine, Paracelsus Private Medical University, 
      Salzburg, Austria.
FAU - Oberkofler, H
AU  - Oberkofler H
FAU - Weitgasser, R
AU  - Weitgasser R
FAU - Mackevics, V
AU  - Mackevics V
FAU - Krempler, F
AU  - Krempler F
FAU - Paulweber, B
AU  - Paulweber B
FAU - Patsch, W
AU  - Patsch W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061212
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Adiponectin)
RN  - 0 (SREBF1 protein, human)
RN  - 0 (Sterol Regulatory Element Binding Protein 1)
SB  - IM
MH  - Adiponectin/*blood
MH  - Aged
MH  - Austria/epidemiology
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/*genetics/metabolism
MH  - Female
MH  - Genetic Predisposition to Disease/epidemiology
MH  - Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Prevalence
MH  - Risk Factors
MH  - Sterol Regulatory Element Binding Protein 1/*genetics/metabolism
EDAT- 2006/12/13 09:00
MHDA- 2007/12/20 09:00
CRDT- 2006/12/13 09:00
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2007/12/20 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
AID - 0803505 [pii]
AID - 10.1038/sj.ijo.0803505 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2007 Jul;31(7):1099-103. doi: 10.1038/sj.ijo.0803505. Epub 
      2006 Dec 12.