PMID- 17160447
OWN - NLM
STAT- MEDLINE
DCOM- 20070907
LR  - 20181113
IS  - 0301-1623 (Print)
IS  - 0301-1623 (Linking)
VI  - 38
IP  - 3-4
DP  - 2006
TI  - Nutritional and inflammatory status influence darbepoetin dose in pre-dialysis 
      elderly patients.
PG  - 811-3
AB  - Anaemia is a common finding in elderly patients particularly in those with 
      chronic kidney disease. Effective correction of anaemia improves survival and 
      quality of life. The association between anaemia and a poor nutritional status as 
      well as the presence of inflammation has already been documented. The aim of our 
      study was to assess the impact of the nutritional and inflammatory status on 
      darbepoetin dose requirements of elderly patients followed in a "Chronic Kidney 
      Disease" outpatient clinic. We included 71 elderly patients (age>or=65 years) in 
      a "Chronic Kidney Disease" outpatient clinic. Creatinine Clearance (CrCl) was 
      estimated according to the Cockroft-Gault equation. Nutritional status was 
      evaluated by biochemical and anthropometric parameters. Tumour Necrosis 
      Factor-alpha (TNF-alpha), Interleukin-6 (IL-6) and high sensitivity C-reactive 
      protein (hs-CRP) were used as biomarkers of inflammation. Our patients (56% 
      males) with a mean age of 76.2+/-6.6 years were followed for 33.1+/-43.6 months. 
      Mean eCrCl was 13.5+/-7.2 ml/mn/1.73 m2. All patients were under supplemental 
      iron therapy and 74.7% needed darbepoietin (0.762+/-0.6 (microg/kg/week) to 
      correct anaemia. Among the several variables regressed on darbepoietin dose, in a 
      multiple regression model, only Hb, IL-6 and TNF-alpha levels and SGA score 
      predicted the need for higher doses of darbepoietin. (r=0.677; r2=0.459). In 
      Conclusion, in our pre-dialysis elderly patients, markers of a poor nutritional 
      status (SGA and albumin) and inflammation (IL-6 and TNF-alpha) independently 
      predicted the use of higher doses of darbepoietin to correct anaemia.
FAU - Neves, P L
AU  - Neves PL
AD  - Servico de Nefrologia, Hospital Distrital de Faro, Rua Leao Penedo, 8000, Faro, 
      Portugal. plneves@hdfaro.min-saude.pt
FAU - Morgado, E
AU  - Morgado E
FAU - Faisca, M
AU  - Faisca M
FAU - Carrasqueira, H
AU  - Carrasqueira H
FAU - Baptista, A
AU  - Baptista A
FAU - Silva, A P
AU  - Silva AP
LA  - eng
PT  - Journal Article
DEP - 20061207
PL  - Netherlands
TA  - Int Urol Nephrol
JT  - International urology and nephrology
JID - 0262521
RN  - 0 (Hematinics)
RN  - 11096-26-7 (Erythropoietin)
RN  - 15UQ94PT4P (Darbepoetin alfa)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Darbepoetin alfa
MH  - Erythropoietin/administration & dosage/*analogs & derivatives
MH  - Female
MH  - Hematinics/*administration & dosage
MH  - Humans
MH  - *Inflammation
MH  - Male
MH  - Nutritional Status/*drug effects
MH  - Renal Dialysis
EDAT- 2006/12/13 09:00
MHDA- 2007/09/08 09:00
CRDT- 2006/12/13 09:00
PHST- 2006/03/08 00:00 [accepted]
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2007/09/08 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
AID - 10.1007/s11255-006-0077-3 [doi]
PST - ppublish
SO  - Int Urol Nephrol. 2006;38(3-4):811-3. doi: 10.1007/s11255-006-0077-3. Epub 2006 
      Dec 7.