PMID- 17161183
OWN - NLM
STAT- MEDLINE
DCOM- 20070103
LR  - 20061212
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 41
IP  - 12
DP  - 2006 Dec
TI  - The role of monocyte chemoattractant protein-1 in biliary atresia.
PG  - 1967-72
AB  - BACKGROUND: The aim of this study was to explain the role of monocyte 
      chemoattractant protein-1 (MCP-1) in biliary atresia (BA). METHODS: 
      Concentrations of serum MCP-1 and collagen type IV were measured in 38 patients 
      with BA by using commercially available kits. MCP-1 was also assessed in liver 
      biopsy specimens by using immunohistochemistry. Subjects were classified into 
      groups. Group 1 comprised BA patients with normal liver function (n = 13), group 
      II comprised BA patients with moderate liver dysfunction (n = 18), group III 
      comprised BA patients older than 20 years awaiting liver transplantation (n = 7), 
      and the control group comprised age-matched patients without evidence of liver 
      disease (n = 23). RESULTS: Serum MCP-1 levels were significantly increased in 
      group II compared with group I (P < .0001) and the control group (P < .0001). 
      Serum MCP-1 levels in group III were lower than in the control group (P < .0001). 
      There was a significant linear correlation between serum MCP-1 levels and type IV 
      collagen levels in group II. Group II subjects with portal hypertension (PH) had 
      higher MCP-1 levels than those without PH (P = .0009). Biopsy specimens showed 
      MCP-1 was expressed mainly on biliary epithelial cells, vascular endothelial 
      cells, and hepatocytes in group II. CONCLUSIONS: These findings suggest that 
      MCP-1 probably plays a significant role in the development of progressive liver 
      fibrosis in BA.
FAU - Kobayashi, Hiroyuki
AU  - Kobayashi H
AD  - Department of Pediatric General and Urogenital Surgery, Juntendo University 
      School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan. koba@med.juntendo.ac.jp
FAU - Tamatani, Takuya
AU  - Tamatani T
FAU - Tamura, Tsuyoshi
AU  - Tamura T
FAU - Kusafuka, Junichi
AU  - Kusafuka J
FAU - Koga, Hiroyuki
AU  - Koga H
FAU - Yamataka, Atsuyuki
AU  - Yamataka A
FAU - Lane, Geoffrey J
AU  - Lane GJ
FAU - Miyahara, Katsumi
AU  - Miyahara K
FAU - Sueyoshi, Noriyoshi
AU  - Sueyoshi N
FAU - Miyano, Takeshi
AU  - Miyano T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
RN  - 0 (Chemokine CCL2)
RN  - 0 (Collagen Type IV)
SB  - IM
MH  - Adolescent
MH  - Biliary Atresia/blood/complications/*physiopathology
MH  - Chemokine CCL2/*blood
MH  - Child
MH  - Child, Preschool
MH  - Collagen Type IV/blood
MH  - Digestive System Surgical Procedures
MH  - Disease Progression
MH  - Humans
MH  - Hypertension, Portal/etiology/physiopathology
MH  - Liver Cirrhosis/etiology/*physiopathology
MH  - Treatment Outcome
EDAT- 2006/12/13 09:00
MHDA- 2007/01/04 09:00
CRDT- 2006/12/13 09:00
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2007/01/04 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
AID - S0022-3468(06)00582-3 [pii]
AID - 10.1016/j.jpedsurg.2006.08.018 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2006 Dec;41(12):1967-72. doi: 10.1016/j.jpedsurg.2006.08.018.