PMID- 17161391
OWN - NLM
STAT- MEDLINE
DCOM- 20070313
LR  - 20181113
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1130
IP  - 1
DP  - 2007 Jan 26
TI  - Developmental and injury-induced expression of alpha1beta1 and alpha6beta1 
      integrins in the rat spinal cord.
PG  - 54-66
AB  - Loss and damage to blood vessels are thought to contribute to secondary tissue 
      loss after spinal cord injury. Integrins might be therapeutic targets to protect 
      the vasculature and/or promote angiogenesis, as their activation can promote 
      tubule formation and survival of endothelial cells in vitro. Here, we show that 
      immunostaining with an antibody against the alpha1beta1 integrin heterodimer is 
      present only in blood vessels from postnatal day 1 (P1) through adulthood in 
      Sprague-Dawley rats. After a spinal cord contusion at T9 in adults, the area of 
      alpha1beta1 integrin positive blood vessels increases within 11 mm from the 
      injury site at 3 days post-injury and remains prominent within the injured core 
      only at 7 days. Staining for the alpha6beta1 integrin heterodimer increases in 
      blood vessels between P10 and adulthood and is present in preganglionic neurons 
      of the intermediolateral cell column (IML) at all ages. The alpha6beta1 integrin 
      is also expressed by motor neurons postnatally, and oligodendrocyte precursors 
      (OPCs), as previously reported. After the contusion, the area of 
      alpha6beta1-stained blood vessels is increased at 3 days and most prominently, 1 
      mm from the injury site, followed by a significant reduction at 7 days, when 
      alpha6beta1 integrin staining is most prominent around the injured core. Staining 
      is also present in a subset of microglia and/or macrophages. These results raise 
      the possibility that alpha1beta1 and alpha6beta1 integrins in blood vessels might 
      be targeted to reduce blood vessel loss and promote angiogenesis, which may 
      promote tissue sparing after spinal cord injury.
FAU - Baker, K Adam
AU  - Baker KA
AD  - Kentucky Spinal Cord Injury Research Center, Department of Neurological Surgery, 
      MDR Building, Room 616, University of Louisville, Louisville, KY, USA.
FAU - Hagg, Theo
AU  - Hagg T
LA  - eng
GR  - P20 RR015576/RR/NCRR NIH HHS/United States
GR  - R01 NS045734/NS/NINDS NIH HHS/United States
GR  - RR15576/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20061211
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Integrin alpha1beta1)
RN  - 0 (Integrin alpha6beta1)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Blood Vessels/*metabolism
MH  - Female
MH  - Integrin alpha1beta1/*metabolism
MH  - Integrin alpha6beta1/*metabolism
MH  - Motor Neurons/metabolism
MH  - Neovascularization, Physiologic/*physiology
MH  - Oligodendroglia/cytology/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord/blood supply/cytology/metabolism
MH  - Spinal Cord Injuries/*metabolism
MH  - Stem Cells/cytology/metabolism
MH  - Thoracic Vertebrae
MH  - Time Factors
MH  - Wound Healing/physiology
PMC - PMC1794000
MID - NIHMS16752
EDAT- 2006/12/13 09:00
MHDA- 2007/03/14 09:00
PMCR- 2008/01/31
CRDT- 2006/12/13 09:00
PHST- 2006/05/24 00:00 [received]
PHST- 2006/10/20 00:00 [revised]
PHST- 2006/10/26 00:00 [accepted]
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2007/03/14 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
PHST- 2008/01/31 00:00 [pmc-release]
AID - S0006-8993(06)03191-X [pii]
AID - 10.1016/j.brainres.2006.10.072 [doi]
PST - ppublish
SO  - Brain Res. 2007 Jan 26;1130(1):54-66. doi: 10.1016/j.brainres.2006.10.072. Epub 
      2006 Dec 11.