PMID- 17161914
OWN - NLM
STAT- MEDLINE
DCOM- 20070411
LR  - 20181113
IS  - 0306-4522 (Print)
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 144
IP  - 3
DP  - 2007 Feb 9
TI  - The select action of hippocampal calcium calmodulin protein kinase II in 
      mediating exercise-enhanced cognitive function.
PG  - 825-33
AB  - We found that a single week of exercise enhanced cognitive function on the Morris 
      water maze (MWM), such that exercise animals were significantly better than 
      sedentary controls at learning and recalling the location of the platform. In 
      order to elucidate the role that calcium calmodulin protein kinase II (CAMKII) 
      holds in mediating the exercise-induced enhancement in learning and memory, a 
      specific antagonist of CAMKII, KN-62, was used to block CAMKII in the rat 
      hippocampus during a 1-week voluntary exercise period. Following, a 
      two-trial-per-day MWM was performed for five consecutive days, succeeded by a 
      probe trial 2 days later. Inhibiting CAMKII action during exercise blocked the 
      ability of exercise to enhance memory retention on the MWM; the recall abilities 
      of exercise animals receiving the CAMKII blocker were significantly worse than 
      those of both sedentary and exercise controls. Conversely, CAMKII may not play a 
      significant role in mediating the effects of exercise on learning acquisition as 
      inhibiting CAMKII failed to block the exercise-induced enhancement in learning 
      acquisition. Our results also show that CAMKII activation early during MWM 
      learning may be counterproductive to learning acquisition, as exercising animals 
      given the CAMKII inhibitor performed significantly (P<0.001) better than 
      exercising control animals and sedentary controls only on day 2 of the MWM. 
      Inhibiting CAMKII also blocked the exercise-induced upregulation of molecules 
      critical for learning and memory, brain-derived neurotrophic factor (BDNF) and 
      the transcription activator cAMP response-element-binding protein, which is 
      regulated by and downstream to BDNF action. These findings indicate that 
      hippocampal CAMKII may have a refined role in mediating the effects of exercise 
      on cognition, selectively functioning to regulate memory retention.
FAU - Vaynman, S
AU  - Vaynman S
AD  - Department of Physiological Science, UCLA, 621 Charles E. Young Drive, Los 
      Angeles, CA 90095, USA.
FAU - Ying, Z
AU  - Ying Z
FAU - Gomez-Pinilla, F
AU  - Gomez-Pinilla F
LA  - eng
GR  - R01 NS039522/NS/NINDS NIH HHS/United States
GR  - R01 NS045804/NS/NINDS NIH HHS/United States
GR  - R01 NS045804-02/NS/NINDS NIH HHS/United States
GR  - NS 39522/NS/NINDS NIH HHS/United States
GR  - NS 045804/NS/NINDS NIH HHS/United States
GR  - R01 NS050465/NS/NINDS NIH HHS/United States
GR  - R01 NS050465-02/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20061211
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Enzyme Inhibitors)
RN  - 63HM46XPOW (KN 62)
RN  - 84477-87-2 (1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
SB  - IM
MH  - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives/pharmacology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - CREB-Binding Protein/metabolism
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2
MH  - Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors/*metabolism
MH  - Cognition/*physiology
MH  - Down-Regulation/physiology
MH  - Enzyme Inhibitors/pharmacology
MH  - Exercise Therapy/methods
MH  - Hippocampus/*enzymology
MH  - Learning/physiology
MH  - Male
MH  - Maze Learning/physiology
MH  - Memory/physiology
MH  - Physical Conditioning, Animal/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Up-Regulation/physiology
PMC - PMC2805704
MID - NIHMS17398
EDAT- 2006/12/13 09:00
MHDA- 2007/04/12 09:00
PMCR- 2010/01/12
CRDT- 2006/12/13 09:00
PHST- 2006/06/27 00:00 [received]
PHST- 2006/09/21 00:00 [revised]
PHST- 2006/10/10 00:00 [accepted]
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2007/04/12 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
PHST- 2010/01/12 00:00 [pmc-release]
AID - S0306-4522(06)01372-8 [pii]
AID - 10.1016/j.neuroscience.2006.10.005 [doi]
PST - ppublish
SO  - Neuroscience. 2007 Feb 9;144(3):825-33. doi: 10.1016/j.neuroscience.2006.10.005. 
      Epub 2006 Dec 11.