PMID- 17162248
OWN - NLM
STAT- MEDLINE
DCOM- 20070109
LR  - 20080602
IS  - 1931-5244 (Print)
IS  - 1878-1810 (Linking)
VI  - 148
IP  - 6
DP  - 2006 Dec
TI  - Mechanisms of autoantibody production and the relationship between autoantibodies 
      and the clinical manifestations in Sjogren's syndrome.
PG  - 281-8
AB  - The major target organs of Sjogren's syndrome (SS) are lacrimal glands and 
      salivary glands where prominent lymphocytic infiltration occurs, which may induce 
      varying levels of autoantibody production. Multiple factors, including 
      environmental stress, viral infection, hormonal imbalance, and apoptosis, are 
      thought to be involved in the pathogenesis of SS. Production of anti-SS-A/Ro and 
      anti-SS-B/La antibodies is thought to be regulated by the presentation of 
      autoantigens in context with an aberrant expression pattern of human leukocyte 
      antigen (HLA) in situ. Molecular mimicry with some viral sequences is also 
      hypothesized. The apoptosis-resistance phenotype of B cells in labial salivary 
      glands (LSGs) of SS is important in autoantibody production. CD40/CD40L (CD40 
      ligand) and Bcl-2 family proteins, in tandem with B cell-activating factor 
      (BAFF), are supposed to protect infiltrating lymphocytes from apoptosis. 
      Anti-muscarinic3 receptor antibody plays an important role in cholinergic 
      hyperresponsiveness in SS. Fragmentation of autoantigens such as SS-B/La or 
      alfa-fodrin during the process of apoptosis causes the redistribution of these 
      autoantigens, leading to the production of autoantibodies in SS. In this review, 
      the role of autoantibodies found in SS, corresponding to clinical aspects of each 
      antibody as well as the mechanisms of production, is discussed.
FAU - Nakamura, Hideki
AU  - Nakamura H
AD  - The First Department of Internal Medicine, Graduate School of Biomedical 
      Sciences, Nagasaki University, Nagasaki City, Nagasaki, Japan. 
      nakamura_hideki911@yahoo.co.jp
FAU - Kawakami, Atsushi
AU  - Kawakami A
FAU - Eguchi, Katsumi
AU  - Eguchi K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Transl Res
JT  - Translational research : the journal of laboratory and clinical medicine
JID - 101280339
RN  - 0 (Antigens)
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Antigen-Antibody Reactions
MH  - Antigens/immunology
MH  - Apoptosis/immunology
MH  - *Autoantibodies/biosynthesis/blood
MH  - Humans
MH  - Models, Immunological
MH  - Sjogren's Syndrome/genetics/*immunology/pathology
RF  - 54
EDAT- 2006/12/13 09:00
MHDA- 2007/01/11 09:00
CRDT- 2006/12/13 09:00
PHST- 2006/03/27 00:00 [received]
PHST- 2006/07/10 00:00 [revised]
PHST- 2006/07/15 00:00 [accepted]
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2007/01/11 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
AID - S1931-5244(06)00298-2 [pii]
AID - 10.1016/j.trsl.2006.07.003 [doi]
PST - ppublish
SO  - Transl Res. 2006 Dec;148(6):281-8. doi: 10.1016/j.trsl.2006.07.003.