PMID- 17162724
OWN - NLM
STAT- MEDLINE
DCOM- 20070321
LR  - 20220311
IS  - 1380-3395 (Print)
IS  - 1380-3395 (Linking)
VI  - 29
IP  - 1
DP  - 2007 Jan
TI  - The speed of lexical activation is altered in Parkinson's disease.
PG  - 73-85
AB  - Disturbed comprehension of complex noncanonical sentences in Parkinson's disease 
      (PD) has been linked to dopamine depletion and delayed lexical retrieval. The aim 
      of the present study was to replicate findings of delayed lexical activation in 
      PD patients with noncanonical sentence processing difficulties, and investigate 
      the influence of dopamine depletion on these changes to lexical access. In the 
      first experiment, 20 patients with PD (tested whilst 'on' dopaminergic 
      medication) and 23 controls participated in a list priming experiment. In this 
      paradigm, stimuli are presented as a continuous list of words/nonwords, and 
      semantic priming effects were measured across inter-stimulus intervals (ISIs) of 
      500 ms, 1000 ms and 1500 ms, with data analyzed using multivariate analyses of 
      variance. The results revealed longer delays in lexical activation for PD 
      patients with poor comprehension of noncanonical sentences, suggesting that the 
      speed of lexical access may be compromised in PD, and that this feature may 
      contribute to certain sentencecomprehension difficulties. In the second 
      experiment, 7 patients with PD who participated in the first experiment, 
      performed the same lexical decision task while 'off' their dopaminergic 
      medication. Semantic priming effects were measured across ISIs of 500 ms and 1500 
      ms. Within group comparisons revealed a different pattern of semantic priming for 
      the PD patients when 'on' compared to 'off' medication, providing further support 
      for a dopaminergic influence on the speed of information processing and lexical 
      activation.
FAU - Angwin, Anthony J
AU  - Angwin AJ
AD  - Centre for Research in Language Processing and Linguistics, The University of 
      Queensland, Brisbane, Australia.
FAU - Chenery, Helen J
AU  - Chenery HJ
FAU - Copland, David A
AU  - Copland DA
FAU - Murdoch, Bruce E
AU  - Murdoch BE
FAU - Silburn, Peter A
AU  - Silburn PA
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Clin Exp Neuropsychol
JT  - Journal of clinical and experimental neuropsychology
JID - 8502170
RN  - 0 (Dopamine Agents)
RN  - 46627O600J (Levodopa)
SB  - IM
MH  - Acoustic Stimulation/methods
MH  - Aged
MH  - Case-Control Studies
MH  - Comprehension/drug effects/*physiology
MH  - Dopamine Agents/therapeutic use
MH  - Female
MH  - Humans
MH  - Levodopa/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Paired-Associate Learning/drug effects/*physiology
MH  - Parkinson Disease/drug therapy/*physiopathology
MH  - Reaction Time/drug effects/*physiology
MH  - *Semantics
MH  - Time Factors
EDAT- 2006/12/13 09:00
MHDA- 2007/03/22 09:00
CRDT- 2006/12/13 09:00
PHST- 2006/12/13 09:00 [pubmed]
PHST- 2007/03/22 09:00 [medline]
PHST- 2006/12/13 09:00 [entrez]
AID - U7485N36865NX8VQ [pii]
AID - 10.1080/13803390500507188 [doi]
PST - ppublish
SO  - J Clin Exp Neuropsychol. 2007 Jan;29(1):73-85. doi: 10.1080/13803390500507188.