PMID- 17164744
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20131121
IS  - 0392-9590 (Print)
IS  - 0392-9590 (Linking)
VI  - 25
IP  - 4
DP  - 2006 Dec
TI  - A prospective patient observational study of the role of hyperhomocysteinemia in 
      restenosis in patients undergoing infrainguinal angioplasty or bypass procedures.
PG  - 378-84
AB  - AIM: The aim of this study was to examine the correlation between elevated plasma 
      homocysteine (HCy) and restenosis/occlusion in patients undergoing infrainguinal 
      angioplasty or bypass grafting. METHODS: Fifty-three patients presenting to the 
      Northern Vascular Unit were sequentially recruited to the study and prospectively 
      followed up for 12 months post-infrainguinal angioplasty or bypass surgery. 
      Plasma HCy was measured preprocedure and at least 3 months postprocedure using 
      the Abbott IMx system. Hyperhomocysteinemia (HHCy) was taken at a level >15 
      microM/L. All patients were serially duplex scanned at 6 weeks, and 3, 6, 9 and 
      12 months. Kaplan-Meier analysis was performed to assess the restenosis/occlusion 
      rate in patients with HHCy versus controls. Analysis of correlation between risk 
      factors for restenosis/occlusion was performed using the Pearson correlation 
      coefficient. In addition, logistic regression analysis was performed. RESULTS: 
      Forty-eight percent of procedures was performed in patients with HHCy. There were 
      18 graft stenoses/occlusions, and 13 restenoses/occlusions postangioplasty. HHCy 
      did not correlate with an increased risk of restenosis/occlusion (P=0.79). There 
      was a significant correlation between HCy, age, folate and cholesterol levels. 
      Logistic regression analysis revealed no factors that correlated with failure of 
      therapeutic intervention. CONCLUSIONS: This study does not support the hypothesis 
      that HHCy is associated with an increased risk of restenosis after vascular 
      intervention.
FAU - Hansrani, M
AU  - Hansrani M
AD  - Department of Surgery, Freeman Hospital, Newcastle upon Tyne, UK.
FAU - Oates, C
AU  - Oates C
FAU - Stansby, G
AU  - Stansby G
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Int Angiol
JT  - International angiology : a journal of the International Union of Angiology
JID - 8402693
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anastomosis, Surgical
MH  - Angioplasty
MH  - Atherosclerosis/blood/*etiology/*surgery
MH  - Female
MH  - Groin
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/*complications
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Recurrence
EDAT- 2006/12/14 09:00
MHDA- 2007/06/22 09:00
CRDT- 2006/12/14 09:00
PHST- 2006/12/14 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2006/12/14 09:00 [entrez]
PST - ppublish
SO  - Int Angiol. 2006 Dec;25(4):378-84.