PMID- 17164818
OWN - NLM
STAT- MEDLINE
DCOM- 20070831
LR  - 20150311
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 32
IP  - 7
DP  - 2007 Jul
TI  - Stressor-specific regulation of distinct brain-derived neurotrophic factor 
      transcripts and cyclic AMP response element-binding protein expression in the 
      postnatal and adult rat hippocampus.
PG  - 1504-19
AB  - Stress regulation of brain-derived neurotrophic factor (BDNF) is implicated in 
      the hippocampal damage observed in depression. BDNF has a complex gene structure 
      with four 5' untranslated exons (I-IV) with unique promoters, and a common 3' 
      coding exon (V). To better understand the stress regulation of BDNF, we addressed 
      whether distinct stressors differentially regulate exon-specific BDNF transcripts 
      in the postnatal and adult hippocampus. The early life stress of maternal 
      separation (MS) resulted in a time point-dependent differential upregulation of 
      BDNF transcripts restricted to early postnatal life (P14-BDNF II, P21-BDNF IV, 
      V). In adulthood, distinct stressors regulated BDNF transcripts in a signature 
      manner. Immobilization stress, administered once, decreased all BDNF splice 
      variants but had differing effects on BDNF I/II (increase) and III/IV (decrease) 
      when administered chronically. Although immobilization stress reduced BDNF (V) 
      mRNA, chronic unpredictable stress did not influence total BDNF despite altering 
      specific BDNF transcripts. Furthermore, a prior history of MS altered the 
      signature pattern in which adult-onset stress regulated specific BDNF 
      transcripts. We also examined the expression of cyclic AMP response 
      element-binding protein (CREB), an upstream transcriptional activator of BDNF, 
      and observed a CREB induction in the postnatal hippocampus following MS. As a 
      possible consequence of enhanced CREB and BDNF expression following MS, we 
      examined hippocampal progenitor proliferation and observed a significant increase 
      restricted to early life. These results suggest that alterations in CREB/BDNF may 
      contribute to the generation of individual differences in stress neurocircuitry, 
      providing a substrate for altered vulnerability to depressive disorders.
FAU - Nair, Amrita
AU  - Nair A
AD  - Department of Biological Sciences, Tata Institute of Fundamental Research, 
      Mumbai, India.
FAU - Vadodaria, Krishna C
AU  - Vadodaria KC
FAU - Banerjee, Sunayana B
AU  - Banerjee SB
FAU - Benekareddy, Madhurima
AU  - Benekareddy M
FAU - Dias, Brian G
AU  - Dias BG
FAU - Duman, Ronald S
AU  - Duman RS
FAU - Vaidya, Vidita A
AU  - Vaidya VA
LA  - eng
GR  - 1R03 TW 006257-01/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20061213
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cell Differentiation/physiology
MH  - Cyclic AMP Response Element-Binding Protein/*genetics
MH  - Gene Expression Regulation, Developmental/*genetics
MH  - Hippocampus/*growth & development/*metabolism
MH  - Male
MH  - Maternal Deprivation
MH  - Neural Pathways/growth & development/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stem Cells/metabolism
MH  - Stress, Psychological/*metabolism/physiopathology
MH  - Transcriptional Activation/physiology
MH  - Up-Regulation/physiology
EDAT- 2006/12/14 09:00
MHDA- 2007/09/01 09:00
CRDT- 2006/12/14 09:00
PHST- 2006/12/14 09:00 [pubmed]
PHST- 2007/09/01 09:00 [medline]
PHST- 2006/12/14 09:00 [entrez]
AID - 1301276 [pii]
AID - 10.1038/sj.npp.1301276 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2007 Jul;32(7):1504-19. doi: 10.1038/sj.npp.1301276. 
      Epub 2006 Dec 13.