PMID- 17165551
OWN - NLM
STAT- MEDLINE
DCOM- 20100608
LR  - 20161018
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 24
IP  - 5
DP  - 2006 Sep
TI  - [Separation of sitafloxacin epimers by capillary electrophoresis].
PG  - 513-5
AB  - Sitafloxacin epimers were separated by capillary zone electrophoresis using 
      gamma-cyclodextrin (gamma-CD) and D-phenylalanine (D-Phe) as chiral selector. The 
      effects of the concentrations of gamma-CD, D-Phe, Cu2+ and pH of buffer were 
      investigated. An uncoated fused-silica capillary of 50 microm i.d. and 60 cm 
      (effective length 52.5 cm) was used. The capillary temperature was maintained at 
      25 degrees C. Samples were injected under a pressure of 7 kPa for 5 s and 
      separated at 15 kV. A baseline separation of sitafloxacin epimers was achieved 
      with a background electrolyte of 10 mmol/L KH2PO4-K2HPO4(pH 4.5), 10 mmol/L 
      CuSO4, 20 mmol/L gamma-CD and 10 mmol/L D-Phe. The linear range for sitafloxacin 
      was 32 -400 mg/L (0.996). The relative standard deviations (RSDs) of migration 
      time and peak area were less than 1.9% and 3.8% respectively. This method can be 
      applied in qualitative and quantitative analysis for sitafloxacin epimers.
FAU - Yuan, Pei
AU  - Yuan P
AD  - Pharmaceutical Department, Chongqing University of Medical Sciences, Chongqing 
      400016, China. ypll1971@163.com
FAU - Lin, Lei
AU  - Lin L
FAU - Fan, Qi
AU  - Fan Q
FAU - Zeng, Linggao
AU  - Zeng L
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Fluoroquinolones)
RN  - 9TD681796G (sitafloxacin)
SB  - IM
MH  - Electrophoresis, Capillary
MH  - Fluoroquinolones/*isolation & purification
MH  - Stereoisomerism
EDAT- 2006/12/15 09:00
MHDA- 2010/06/09 06:00
CRDT- 2006/12/15 09:00
PHST- 2006/12/15 09:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
PHST- 2006/12/15 09:00 [entrez]
PST - ppublish
SO  - Se Pu. 2006 Sep;24(5):513-5.