PMID- 17166285
OWN - NLM
STAT- MEDLINE
DCOM- 20070223
LR  - 20181113
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 8
IP  - 6
DP  - 2006
TI  - HLA-C locus alleles may modulate the clinical expression of psoriatic arthritis.
PG  - R185
AB  - The aim of the present study was to evaluate the relative contribution of human 
      leukocyte antigen (HLA)-C locus alleles in determining the risk and the clinical 
      expression of psoriatic arthritis (PsA). One hundred PsA patients were randomly 
      selected and grouped into three disease subsets: oligoarthritis (n = 40), 
      polyarthritis (n = 25) and spondylitis (n = 35). The HLA-C locus profile of this 
      cohort was studied by methods based on molecular biology and was compared with 
      that of 45 patients with psoriasis vulgaris and 177 healthy blood donors from the 
      same ethnic origin. HLA-Cw*0602 was found associated with both psoriasis (odds 
      ratio (OR) 6.2; 95% confidence interval (CI) 3.1 to 12.5; p < 0.0001) and PsA (OR 
      6.2; 95% CI 3.6 to 10.8; p < 0.0001); however, this allele was equally found 
      among the PsA subsets. HLA-Cw6-positive patients showed a longer 
      psoriasis-arthritis latency period (p = 0.012). HLA-Cw*0701 was found 
      under-represented in PsA in comparison with controls (OR 0.5; 95% CI 0.3 to 0.9; 
      p = 0.04), as was HLA-Cw*0802 (OR 0.3; 95% CI 0.08 to 1; p = 0.05). A positive 
      association was found between psoriatic spondylitis and HLA-Cw*0702 (OR 5.0; 95% 
      CI 1.4 to 25; p = 0.01). HLA-Cw*0602 seems to confer a general risk for 
      psoriasis, but the presence of other HLA-C locus alleles may explain an 
      additional arthritogenic risk. HLA-C alleles may modulate some aspects of the 
      clinical expression of PsA, but these findings need confirmation.
FAU - Queiro, Ruben
AU  - Queiro R
AD  - Rheumatology Service, Hospital Universitario Central de Asturias (HUCA), 
      C/Celestino Villamil s/n, 33006, Oviedo, Spain. ruquei@mixmail.com
FAU - Gonzalez, Segundo
AU  - Gonzalez S
FAU - Lopez-Larrea, Carlos
AU  - Lopez-Larrea C
FAU - Alperi, Mercedes
AU  - Alperi M
FAU - Sarasqueta, Cristina
AU  - Sarasqueta C
FAU - Riestra, Jose Luis
AU  - Riestra JL
FAU - Ballina, Javier
AU  - Ballina J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Alleles
MH  - Arthritis, Psoriatic/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/genetics
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
PMC - PMC1794531
EDAT- 2006/12/15 09:00
MHDA- 2007/02/24 09:00
PMCR- 2006/12/13
CRDT- 2006/12/15 09:00
PHST- 2006/08/15 00:00 [received]
PHST- 2006/11/04 00:00 [revised]
PHST- 2006/12/13 00:00 [accepted]
PHST- 2006/12/15 09:00 [pubmed]
PHST- 2007/02/24 09:00 [medline]
PHST- 2006/12/15 09:00 [entrez]
PHST- 2006/12/13 00:00 [pmc-release]
AID - ar2097 [pii]
AID - 10.1186/ar2097 [doi]
PST - ppublish
SO  - Arthritis Res Ther. 2006;8(6):R185. doi: 10.1186/ar2097.