PMID- 17166355
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20061214
IS  - 1003-0603 (Print)
IS  - 1003-0603 (Linking)
VI  - 18
IP  - 12
DP  - 2006 Dec
TI  - [Effect of high volume hemofiltration on pulmonary surfactant protein in 
      endotoxin induced acute lung injury in dog].
PG  - 737-9
AB  - OBJECTIVE: To explore the effect of high volume hemofiltration (HVHF) on 
      pulmonary surfactant protein (SP) in endotoxin induced acute lung injury (ALI) in 
      dogs. METHODS: Sixteen healthy male mongrel dogs were given 
      lipopolysaccharide(LPS 650 mug/kg) via central vein within 30 minutes. After the 
      reproduction of the model, they were divided into two groups randomly (n=8). One 
      group received the treatment of HVHF and mechanical ventilation (MV, treatment 
      group), while another received only MV (model group). Parameters of arterial 
      blood gas and respiratory mechanics were recorded at basic values, after 
      reproduction of the experimental model, and 1, 2 and 4 hours after HVHF. Content 
      of SP-B in lung tissue homogenate was measured by protein Western blot. RESULTS: 
      After injection of LPS, partial pressure of oxygen in artery (PaO(2)) and 
      PaO(2)/fractional concentration of inspired oxygen (FiO(2)) began to decrease 
      (both P<0.05). PaO(2)/FiO(2) <300 mm Hg (1 mm Hg=0.133 kPa) when ALI was 
      reproduced. PaO(2) and PaO(2)/FiO(2) were higher in treatment group than those in 
      model group 4 hours after HVHF (both P<0.01). Inspiratory resistance of airway 
      (Raw) and peak inspiratory pressure (PIP) in model group were kept stable after 
      MV. Lung dynamic compliance (Cdyn) and lung total compliance (Ctot) in model 
      group were both decreased while ventilatory work of breathing (WOBvent) increased 
      4 hours after MV (all P<0.01). All parameters in the treatment group were kept 
      stable and differences in Cdyn and Ctot were significant at 4 hours after HVHF 
      compared to model group (P<0.01 and P<0.05). Content of SP-B in lung tissue 
      homogenate was significantly higher in treatment group than that in model group 
      (P<0.01). CONCLUSION: HVHF could effectively increase the content of SP-B in lung 
      to prevent aggravation of respiratory mechanics and improve oxygenation.
FAU - Zeng, Zhen-guo
AU  - Zeng ZG
AD  - Intensive Care Unit,the First Hospital Affiliated to Nanchang University, 
      Nanchang 330006, Jiangxi, China.
FAU - Liu, Fen
AU  - Liu F
FAU - Jiang, Rong
AU  - Jiang R
FAU - Zhu, Feng
AU  - Zhu F
FAU - Nie, Cheng
AU  - Nie C
FAU - Qian, Ke-jian
AU  - Qian KJ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
JT  - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo 
      weizhongbing jijiuyixue
JID - 9887521
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Pulmonary Surfactant-Associated Protein B)
SB  - IM
MH  - Acute Lung Injury/chemically induced/*metabolism/therapy
MH  - Animals
MH  - Disease Models, Animal
MH  - Dogs
MH  - *Hemofiltration
MH  - Lipopolysaccharides/toxicity
MH  - Lung/metabolism
MH  - Male
MH  - Pulmonary Surfactant-Associated Protein B/*metabolism
EDAT- 2006/12/15 09:00
MHDA- 2011/06/07 06:00
CRDT- 2006/12/15 09:00
PHST- 2006/12/15 09:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
PHST- 2006/12/15 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006 Dec;18(12):737-9.