PMID- 17166400
OWN - NLM
STAT- MEDLINE
DCOM- 20070320
LR  - 20220227
IS  - 0394-6320 (Print)
IS  - 0394-6320 (Linking)
VI  - 19
IP  - 4
DP  - 2006 Oct-Dec
TI  - Progesterone inhibits mast cell secretion.
PG  - 787-94
AB  - Mast cells are involved in allergic reactions, where they secrete numerous 
      vasoactive, inflammatory and nociceptive mediators in response to immunoglobulin 
      E (IgE) and antigen. However, they have also been implicated in inflammatory 
      conditions, such as painful bladder syndrome/interstitial cystitis (PBS/IC), 
      irritable bowel syndrome (IBS) and migraines, all of which occur more often in 
      women and are exacerbated during ovulation, but are suppressed during pregnancy. 
      Mast cells express high affinity estrogen receptors and estradiol augments their 
      secretion, while tamoxifen inhibits it. Here we report that progesterone (100 
      nM), but not the structurally related cholesterol, inhibits histamine secretion 
      from purified rat peritoneal mast cells stimulated immunologically or by 
      substance P (SP), an effect also documented by electron microscopy. These results 
      suggest that mast cell secretion may be regulated by progesterone and may explain 
      the reduced symptoms of certain inflammatory conditions during pregnancy.
FAU - Vasiadi, M
AU  - Vasiadi M
AD  - Department of Pharmacology and Experimental Therapeutics, Tufts University School 
      of Medicine, Tufts-New England Medical Center, Boston, MA, USA.
FAU - Kempuraj, D
AU  - Kempuraj D
FAU - Boucher, W
AU  - Boucher W
FAU - Kalogeromitros, D
AU  - Kalogeromitros D
FAU - Theoharides, T C
AU  - Theoharides TC
LA  - eng
GR  - DK 42409/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Animals
MH  - Male
MH  - Mast Cells/*drug effects/metabolism
MH  - Progesterone/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2006/12/15 09:00
MHDA- 2007/03/21 09:00
CRDT- 2006/12/15 09:00
PHST- 2006/12/15 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2006/12/15 09:00 [entrez]
AID - 8 [pii]
AID - 10.1177/039463200601900408 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2006 Oct-Dec;19(4):787-94. doi: 
      10.1177/039463200601900408.