PMID- 17166895
OWN - NLM
STAT- MEDLINE
DCOM- 20070723
LR  - 20181113
IS  - 0007-1161 (Print)
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 91
IP  - 6
DP  - 2007 Jun
TI  - Positive correlation between pigment epithelium-derived factor and monocyte 
      chemoattractant protein-1 levels in the aqueous humour of patients with uveitis.
PG  - 737-8
AB  - AIM: To evaluate whether aqueous humour levels of pigment epithelium-derived 
      factor (PEDF) are associated with monocyte chemoattractant protein-1 (MCP-1) in 
      patients with uveitis. METHODS: Aqueous humour levels of MCP-1 and PEDF were 
      determined by ELISA in 34 uveitis samples and 9 cataract control samples. 
      RESULTS: Aqueous humour MCP-1 and PEDF levels were significantly higher in 
      patients with infectious or non-infectious uveitis than in controls (mean (SD) 
      32.3 (10.7) ng/ml vs 4.48 (1.10) ng/ml vs 0.47 (0.10) ng/ml, and 8.40 (1.30) 
      microg/ml vs 5.01 (0.92) microg/ml vs 1.32 (0.22) microg/ml, respectively, 
      p<0.001). A positive correlation between PEDF and MCP-1 was found in patients 
      with uveitis (r = 0.39, p<0.01). CONCLUSION: The results demonstrated that 
      aqueous humour levels of PEDF were positively associated with MCP-1 in patients 
      with uveitis. The present observations suggest that aqueous humour levels of PEDF 
      may be a marker of inflammation in uveitis.
FAU - Yoshida, Yumiko
AU  - Yoshida Y
AD  - Department of Medicine, Division of Cardiovascular Medicine, Kurume University 
      School of Medicine, Kurume 830-0011, Japan.
FAU - Yamagishi, Sho-Ichi
AU  - Yamagishi S
FAU - Matsui, Takanori
AU  - Matsui T
FAU - Nakamura, Kazuo
AU  - Nakamura K
FAU - Imaizumi, Tsutomu
AU  - Imaizumi T
FAU - Yoshimura, Koichi
AU  - Yoshimura K
FAU - Yamakawa, Ryoji
AU  - Yamakawa R
LA  - eng
PT  - Journal Article
DEP - 20061213
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Eye Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Serpins)
RN  - 0 (pigment epithelium-derived factor)
SB  - IM
MH  - Aged
MH  - Aqueous Humor/*chemistry
MH  - Biomarkers/analysis
MH  - Cataract/metabolism
MH  - Chemokine CCL2/*analysis
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Eye Infections/metabolism
MH  - Eye Proteins/*analysis
MH  - Humans
MH  - Middle Aged
MH  - Nerve Growth Factors/*analysis
MH  - Serpins/*analysis
MH  - Uveitis/*metabolism
PMC - PMC1955592
COIS- Competing interests: None declared.
EDAT- 2006/12/15 09:00
MHDA- 2007/07/24 09:00
PMCR- 2010/06/01
CRDT- 2006/12/15 09:00
PHST- 2006/12/15 09:00 [pubmed]
PHST- 2007/07/24 09:00 [medline]
PHST- 2006/12/15 09:00 [entrez]
PHST- 2010/06/01 00:00 [pmc-release]
AID - bjo.2006.109843 [pii]
AID - bj109843 [pii]
AID - 10.1136/bjo.2006.109843 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2007 Jun;91(6):737-8. doi: 10.1136/bjo.2006.109843. Epub 2006 
      Dec 13.