PMID- 17167053
OWN - NLM
STAT- MEDLINE
DCOM- 20070208
LR  - 20181113
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 103
IP  - 52
DP  - 2006 Dec 26
TI  - Calorie restriction up-regulates the plasma membrane redox system in brain cells 
      and suppresses oxidative stress during aging.
PG  - 19908-12
AB  - The plasma membrane (PM) contains redox enzymes that provide electrons for energy 
      metabolism and recycling of antioxidants such as coenzyme Q and alpha-tocopherol. 
      Brain aging and neurodegenerative disorders involve impaired energy metabolism 
      and oxidative damage, but the involvement of the PM redox system (PMRS) in these 
      processes is unknown. Caloric restriction (CR), a manipulation that protects the 
      brain against aging and disease, increased activities of PMRS enzymes 
      (NADH-ascorbate free radical reductase, NADH-quinone oxidoreductase 1, 
      NADH-ferrocyanide reductase, NADH-coenzyme Q10 reductase, and NADH-cytochrome c 
      reductase) and antioxidant levels (alpha-tocopherol and coenzyme Q10) in brain PM 
      during aging. Age-related increases in PM lipid peroxidation, protein carbonyls, 
      and nitrotyrosine were attenuated by CR, levels of PMRS enzyme activities were 
      higher, and markers of oxidative stress were lower in cultured neuronal cells 
      treated with CR serum compared with those treated with ad libitum serum. These 
      findings suggest important roles for the PMRS in protecting brain cells against 
      age-related increases in oxidative and metabolic stress.
FAU - Hyun, Dong-Hoon
AU  - Hyun DH
AD  - Laboratory of Neurosciences and Laboratory of Experimental Gerontology, National 
      Institute on Aging Intramural Research Program, National Institutes of Health, 
      Baltimore, MD 21224, USA.
FAU - Emerson, Scott S
AU  - Emerson SS
FAU - Jo, Dong-Gyu
AU  - Jo DG
FAU - Mattson, Mark P
AU  - Mattson MP
FAU - de Cabo, Rafael
AU  - de Cabo R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061213
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - H4N855PNZ1 (alpha-Tocopherol)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Biomarkers
MH  - Brain/*metabolism
MH  - *Caloric Restriction
MH  - Cell Line, Tumor
MH  - Cell Membrane/*metabolism
MH  - Humans
MH  - Male
MH  - Oxidation-Reduction
MH  - *Oxidative Stress
MH  - Rats
MH  - Up-Regulation
MH  - alpha-Tocopherol/metabolism
PMC - PMC1750890
COIS- The authors declare no conflict of interest.
EDAT- 2006/12/15 09:00
MHDA- 2007/02/09 09:00
PMCR- 2007/06/26
CRDT- 2006/12/15 09:00
PHST- 2006/12/15 09:00 [pubmed]
PHST- 2007/02/09 09:00 [medline]
PHST- 2006/12/15 09:00 [entrez]
PHST- 2007/06/26 00:00 [pmc-release]
AID - 0608008103 [pii]
AID - 4492 [pii]
AID - 10.1073/pnas.0608008103 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19908-12. doi: 
      10.1073/pnas.0608008103. Epub 2006 Dec 13.