PMID- 17167495
OWN - NLM
STAT- MEDLINE
DCOM- 20070516
LR  - 20070307
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 8
IP  - 2
DP  - 2007 Mar
TI  - Non-B27 MHC associations of ankylosing spondylitis.
PG  - 115-23
AB  - Ankylosing spondylitis (AS) has been associated with human leukocyte antigen 
      (HLA)-B27 for over 30 years; however, the mechanism of action has remained 
      elusive. Although many studies have reported associations between AS and other 
      genes in the major histocompatibility complex (MHC) in AS, no conclusive results 
      have emerged. To investigate the contribution of non-B27 MHC genes to AS, a large 
      cohort of AS families and controls were B27 typed and genotyped across the 
      region. Interrogation of the data identified a region of 270 kb, lying from 31 
      952 649 to 32 221 738 base pairs from the p-telomere of chromosome 6 and 
      containing 23 genes, which is likely to include genes involved with 
      susceptibility to AS.
FAU - Sims, A-M
AU  - Sims AM
AD  - Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK.
FAU - Barnardo, M
AU  - Barnardo M
FAU - Herzberg, I
AU  - Herzberg I
FAU - Bradbury, L
AU  - Bradbury L
FAU - Calin, A
AU  - Calin A
FAU - Wordsworth, B P
AU  - Wordsworth BP
FAU - Darke, C
AU  - Darke C
FAU - Brown, M A
AU  - Brown MA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061214
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (DNA Primers)
SB  - IM
MH  - Case-Control Studies
MH  - Chromosomes, Human, Pair 6/*genetics
MH  - DNA Primers
MH  - England
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Haplotypes/genetics
MH  - Humans
MH  - Major Histocompatibility Complex/*genetics
MH  - Polymerase Chain Reaction
MH  - Spondylitis, Ankylosing/*genetics
EDAT- 2006/12/15 09:00
MHDA- 2007/05/17 09:00
CRDT- 2006/12/15 09:00
PHST- 2006/12/15 09:00 [pubmed]
PHST- 2007/05/17 09:00 [medline]
PHST- 2006/12/15 09:00 [entrez]
AID - 6364362 [pii]
AID - 10.1038/sj.gene.6364362 [doi]
PST - ppublish
SO  - Genes Immun. 2007 Mar;8(2):115-23. doi: 10.1038/sj.gene.6364362. Epub 2006 Dec 
      14.