PMID- 17167711
OWN - NLM
STAT- MEDLINE
DCOM- 20070830
LR  - 20191110
IS  - 0034-9887 (Print)
IS  - 0034-9887 (Linking)
VI  - 134
IP  - 9
DP  - 2006 Sep
TI  - [Association between tumor necrosis factor-alpha promoter polymorphisms and type 
      2 diabetes and obesity in Chilean elderly women].
PG  - 1099-106
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) has an increased expression 
      in the adipose tissue of obese subjects and is involved in insulin resistance. 
      AIM: To screen for associations between -308G/A, -238G/A, -376G/A and -163G/A 
      genetic variants of the TNF-alpha gene, diabetes and obesity-related variables. 
      MATERIAL AND METHODS: A group of 263 elderly women aged 60-90 years were 
      recruited. Among them, an oral glucose tolerance test was performed and serum 
      lipids measured in 100 women. TNF-alpha genotypes were determined by polymerase 
      chain reaction (PCR) and analysis of restriction fragment length polymorphisms. 
      RESULTS: No significant differences were found when comparing allele frequencies 
      in TNF-alpha polymorphisms of normal subjects with those having impaired glucose 
      tolerance or type 2 diabetes. After excluding patients with previous diagnosis of 
      diabetes, no significant differences by polymorphism carrier status were found 
      for plasma levels of lipids, glucose and insulin. Additionally, no significant 
      differences were found for the association between variables related to adiposity 
      and the -308G/A polymorphisms. CONCLUSIONS: It is unlikely that polymorphisms in 
      the promoter region of the TNF-alpha gene have a major influence in obesity and 
      diabetes phenotypes in Chilean elderly women.
FAU - Santos M, Jose Luis
AU  - Santos M JL
AD  - Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, 
      Santiago, Chile. jsantos@inta.cl
FAU - Patino G, Ana
AU  - Patino G A
FAU - Angel B, Barbara
AU  - Angel B B
FAU - Martinez H, Jose Alfredo
AU  - Martinez H JA
FAU - Perez B, Francisco
AU  - Perez B F
FAU - Villarroel B, Ana Claudia
AU  - Villarroel B AC
FAU - Sierrasesumaga A, Luis
AU  - Sierrasesumaga A L
FAU - Albala B, Cecilia
AU  - Albala B C
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Asociacion entre polimorfismos de la region promotora del gen del factor de 
      necrosis tumoral alfa (TNF-alfa) con obesidad y diabetes en mujeres chilenas.
DEP - 20061212
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose
MH  - Body Mass Index
MH  - Chile
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin Resistance
MH  - Lipids/blood
MH  - Middle Aged
MH  - Obesity/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic/*genetics
MH  - Polymorphism, Restriction Fragment Length
MH  - *Promoter Regions, Genetic
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2006/12/15 09:00
MHDA- 2007/08/31 09:00
CRDT- 2006/12/15 09:00
PHST- 2006/12/15 09:00 [pubmed]
PHST- 2007/08/31 09:00 [medline]
PHST- 2006/12/15 09:00 [entrez]
AID - S0034-98872006000900003 [pii]
AID - 10.4067/s0034-98872006000900003 [doi]
PST - ppublish
SO  - Rev Med Chil. 2006 Sep;134(9):1099-106. doi: 10.4067/s0034-98872006000900003. 
      Epub 2006 Dec 12.