PMID- 17168119 OWN - NLM STAT- MEDLINE DCOM- 20110414 LR - 20140625 VI - 20 IP - 19 DP - 2006 Oct TI - [Expression of BDNF and trk B in the cochleas of the aged rats]. PG - 894-5 AB - OBJECTIVE: To explore the correlation between the expression of brain derived neurotrophic factor (BDNF) and presbycusis in the cochleae of the aged rats. METHOD: The mRNA expression of BDNF and presbycusis in the cochleas of the aged rats was quantitated by real time PCR. RESULT: The expression of BDNF in the cochleas of the aged rats with presbycusis was obviously less than that in the control group. And the difference was statistically significant. CONCLUSION: The expression of BDNF is closely correlated to presbycusis in the aged rats. FAU - Li, Yuru AU - Li Y AD - Department of Otolaryngology, First Hospital of Harbin Medical University, Harbin 150001, China. FAU - Liu, Delong AU - Liu D FAU - Zhang, Yuanyuan AU - Zhang Y FAU - Wang, Ping AU - Wang P FAU - Du, Baodong AU - Du B LA - chi PT - English Abstract PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - China TA - Lin Chuang Er Bi Yan Hou Ke Za Zhi JT - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology JID - 9426080 RN - 0 (Brain-Derived Neurotrophic Factor) RN - EC 2.7.10.1 (Receptor, trkB) SB - IM MH - *Aging MH - Animals MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Cochlea/*metabolism MH - Rats MH - Rats, Wistar MH - Receptor, trkB/*metabolism EDAT- 2006/12/16 09:00 MHDA- 2011/04/16 06:00 CRDT- 2006/12/16 09:00 PHST- 2006/12/16 09:00 [pubmed] PHST- 2011/04/16 06:00 [medline] PHST- 2006/12/16 09:00 [entrez] PST - ppublish SO - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Oct;20(19):894-5.