PMID- 17169411
OWN - NLM
STAT- MEDLINE
DCOM- 20071018
LR  - 20220317
IS  - 0049-3848 (Print)
IS  - 0049-3848 (Linking)
VI  - 120
IP  - 4
DP  - 2007
TI  - Relationship between soluble P-selectin and inflammatory factors (interleukin-6 
      and C-reactive protein) in colorectal cancer.
PG  - 585-90
AB  - BACKGROUND: Platelets are an important element in the thrombotic process, 
      inflammation and cancer progression. We tested the hypothesis that there is a 
      relationship between platelet activation and inflammation in colorectal cancer 
      patients (CRC). PATIENTS/METHODS: We measured soluble (s) P-selectin (marker of 
      platelet activation), interleukin-6 (IL-6) and C-reactive protein (CRP) (indexes 
      of inflammation) in 42 CRC patients and 38 healthy subjects. CRC patients were 
      divided into two groups: A-24 patients in stages I and II; B-18 patients in stage 
      III. Soluble P-selectin, Interleukin-6 concentration was measured using 
      commercially available immunoenzymatic methods. High sensitivity C-reactive 
      protein (RCRP) concentration was measured by a high sensitivity latex particle 
      turbidimetric immunoassay. RESULTS: Soluble P-selectin, CRP and IL-6 levels were 
      significantly increased as compared to the control group (p<0.001). Plasma levels 
      of sP-selectin, CRP and IL-6 were higher in group B (with metastases) than in 
      group A (without metastases) (p<0.001). CRC patients had a positive correlation 
      between IL-6 and CRP (r=0.7638, p<0.01) and between sP-selectin and IL-6 
      (r=0.5633, p<0.03). CONCLUSION: We observed hyperactivation of blood platelets 
      and inflammatory response in patients with colorectal cancer, also the 
      inflammatory process and platelet activation progress along with colorectal 
      cancer advancement. Our results seem to confirm the relationship of platelet 
      activation with inflammatory response in colorectal cancer patients.
FAU - Dymicka-Piekarska, Violetta
AU  - Dymicka-Piekarska V
AD  - Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, 
      Waszyngtona 15A, 15-274 Bialystok, Poland. vpiekarska@yahoo.com
FAU - Matowicka-Karna, Joanna
AU  - Matowicka-Karna J
FAU - Gryko, Mariusz
AU  - Gryko M
FAU - Kemona-Chetnik, Izabela
AU  - Kemona-Chetnik I
FAU - Kemona, Halina
AU  - Kemona H
LA  - eng
PT  - Journal Article
DEP - 20061212
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
RN  - 0 (P-Selectin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*analysis
MH  - Case-Control Studies
MH  - Colorectal Neoplasms/*blood/*pathology
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - P-Selectin/*blood
MH  - Platelet Activation
MH  - Up-Regulation
EDAT- 2006/12/16 09:00
MHDA- 2007/10/19 09:00
CRDT- 2006/12/16 09:00
PHST- 2006/07/14 00:00 [received]
PHST- 2006/11/02 00:00 [revised]
PHST- 2006/11/02 00:00 [accepted]
PHST- 2006/12/16 09:00 [pubmed]
PHST- 2007/10/19 09:00 [medline]
PHST- 2006/12/16 09:00 [entrez]
AID - S0049-3848(06)00442-7 [pii]
AID - 10.1016/j.thromres.2006.11.002 [doi]
PST - ppublish
SO  - Thromb Res. 2007;120(4):585-90. doi: 10.1016/j.thromres.2006.11.002. Epub 2006 
      Dec 12.