PMID- 17169826
OWN - NLM
STAT- MEDLINE
DCOM- 20070227
LR  - 20221207
IS  - 0277-0903 (Print)
IS  - 0277-0903 (Linking)
VI  - 43
IP  - 10
DP  - 2006 Dec
TI  - High prevalence of skin test positivity in severe or difficult-to-treat asthma.
PG  - 745-52
AB  - BACKGROUND: Skin tests are considered the gold standard for detecting 
      allergen-specific immunoglobulin E (IgE) in the clinical setting and are an 
      important tool for diagnosing and managing allergic asthma. OBJECTIVE: To assess 
      the prevalence of skin testing in patients > or = 12 years enrolled in The 
      Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens 
      (TENOR) study. METHODS: Patients were asked whether they had ever been skin 
      tested and, if so, they were asked to provide the test results. Clinical 
      characteristics were used to compare positive (ST+), negative (ST-), and skin 
      test not done (STND) patients. RESULTS: Of 2,985 patients eligible, 85.8% 
      recalled being skin tested. Of those tested, 93.5% were positive (allergist 
      95.7%, pulmonologist 87.3%). A high proportion of Whites (93.5%) and non-Whites 
      (94.0%) were ST+; however, more non-Whites had never been skin tested (21.7% vs. 
      12.3%, respectively; p < 0.0001). Total serum IgE was 104.6 IU/mL for ST+ 
      patients, 87.1 IU/mL for STND patients, and 32.4 IU/mL for ST- patients. Age at 
      asthma onset, duration of asthma, and the prevalence of atopic disorders and 
      asthma triggers differentiated the ST+ from the ST- group. Disease severity 
      appeared similar between the two groups. In general, values for STND patients 
      were closer to the ST+ group, suggesting that those not tested would have been 
      ST+ if administered a test. CONCLUSIONS: The prevalence of ST+ patients was high 
      in allergy and pulmonology practices, and in White and non-White patients. These 
      data support the utility of a more complete allergic evaluation in severe 
      asthmatics. Skin testing appears associated with disease pathophysiologies in 
      asthma.
FAU - Haselkorn, Tmirah
AU  - Haselkorn T
AD  - Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. 
      haselkorn.tmirah@gene.com
FAU - Borish, Larry
AU  - Borish L
FAU - Miller, Dave P
AU  - Miller DP
FAU - Weiss, Scott T
AU  - Weiss ST
FAU - Wong, Dennis A
AU  - Wong DA
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Allergens/*immunology
MH  - Allergy and Immunology/statistics & numerical data
MH  - Asthma/diagnosis/*immunology/physiopathology/*therapy
MH  - Female
MH  - Humans
MH  - Hypersensitivity/complications/epidemiology
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Pulmonary Medicine/statistics & numerical data
MH  - Severity of Illness Index
MH  - Skin Tests/*statistics & numerical data
MH  - White People/statistics & numerical data
EDAT- 2006/12/16 09:00
MHDA- 2007/02/28 09:00
CRDT- 2006/12/16 09:00
PHST- 2006/12/16 09:00 [pubmed]
PHST- 2007/02/28 09:00 [medline]
PHST- 2006/12/16 09:00 [entrez]
AID - U065P21215321458 [pii]
AID - 10.1080/02770900601031540 [doi]
PST - ppublish
SO  - J Asthma. 2006 Dec;43(10):745-52. doi: 10.1080/02770900601031540.