PMID- 17171202
OWN - NLM
STAT- MEDLINE
DCOM- 20070906
LR  - 20200413
IS  - 0021-7557 (Print)
IS  - 0021-7557 (Linking)
VI  - 82
IP  - 6
DP  - 2006 Nov-Dec
TI  - Manifestations of the human T-cell lymphotropic virus type I infection in 
      childhood and adolescence.
PG  - 411-20
AB  - OBJECTIVES: To review the literature on diseases linked with infection by human 
      T-cell lymphotropic virus type I (HTLV-I) in childhood and adolescence, with 
      focus on clinical aspects, diagnosis, pathogenesis, progression and treatment. 
      SOURCES: Medical literature published during the last 20 years identified using 
      PubMed and MEDLINE and from specialized medical books, with emphasis on infective 
      dermatitis associated with HTLV-I (IDH), on the juvenile form of HTLV-associated 
      myelopathy/tropical spastic paraparesis (HAM/TSP), on adult T-cell 
      leukemia/lymphoma (ATL) and on HTLV-I-associated uveitis. Keywords used to search 
      databases were: HTLV-I-associated infective dermatitis, HTLV-I-associated 
      myelopathy/tropical spastic paraparesis, adult T-cell leukemia/lymphoma, 
      HTLV-I-associated uveitis. SUMMARY OF THE FINDINGS: IDH is a chronic, relapsing 
      and infected dermatitis of childhood which always involves the scalp and which 
      may progress to HAM/TSP and ATL. HAM/TSP is a chronic and incapacitating 
      myelopathy of adults. There are 17 well-documented cases of HAM/TSP in children 
      and adolescents in the literature, 12 of whom are patients with IDH. In contrast 
      with the adult form of the disease, the juvenile form is rapid and progressive. 
      ATL is a type of T-cell leukemia/lymphoma that affects adults and is generally 
      fatal. Eleven of the 24 published reports of ATL in children and adolescents were 
      diagnosed in Brazil. CONCLUSIONS: These diseases are likely to be more common in 
      childhood and adolescence than the literature would suggest. It is advisable that 
      serological testing be performed for HTLV-I in children and adolescents suffering 
      from chronic and relapsing eczema, with signs and symptoms of myelopathy or with 
      a diagnosis of T-cell leukemia/lymphoma. It is important that pediatricians know 
      how to recognize the pediatric manifestations of this infection in order to 
      correctly diagnose them and offer their patients appropriate guidance and 
      treatment.
FAU - Bittencourt, Achilea Lisboa
AU  - Bittencourt AL
AD  - Faculdade de Medicina, Universidade Federal da Bahia (UFBA), Salvador, BA, 
      Brazil. achilea@uol.com.br
FAU - Primo, Janeusa
AU  - Primo J
FAU - Oliveira, Maria Fatima Paim de
AU  - Oliveira MF
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Brazil
TA  - J Pediatr (Rio J)
JT  - Jornal de pediatria
JID - 2985188R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blotting, Western
MH  - Breast Feeding
MH  - Child
MH  - Dermatitis, Atopic/diagnosis
MH  - Diagnosis, Differential
MH  - Eczema/virology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - HTLV-I Infections/*complications/diagnosis/transmission
MH  - Humans
MH  - Infectious Disease Transmission, Vertical
MH  - Leukemia-Lymphoma, Adult T-Cell/diagnosis/virology
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Vision Disorders/virology
RF  - 101
EDAT- 2006/12/16 09:00
MHDA- 2007/09/07 09:00
CRDT- 2006/12/16 09:00
PHST- 2006/12/16 09:00 [pubmed]
PHST- 2007/09/07 09:00 [medline]
PHST- 2006/12/16 09:00 [entrez]
AID - 10.2223/JPED.1573 [doi]
PST - ppublish
SO  - J Pediatr (Rio J). 2006 Nov-Dec;82(6):411-20. doi: 10.2223/JPED.1573.