PMID- 1717175
OWN - NLM
STAT- MEDLINE
DCOM- 19911105
LR  - 20161020
IS  - 1000-0607 (Print)
IS  - 1000-0607 (Linking)
VI  - 16
IP  - 2
DP  - 1991
TI  - [Effect of intracerebral injection of substance P on serotonin contents of 
      several brain regions and its relation with pain threshold, electroacupuncture 
      analgesia in rats].
PG  - 125-8
AB  - The purpose of this study is to observe the effect of intracerebroventricular 
      (icv) and intra-PAG injection of substance P (SP) on serotonin (5-HT) contents of 
      hypothalamus, hippocampus, striatum and its relation with the change of pain 
      threshold, electroacupuncture (EA) analgesia. The results were as follows: (1) 
      After icv injection of SP, the pain threshold and the 5-HT contents of 
      hypothalamus, hippocampus were significantly increased. After depletion of the 
      5-HT contents in brain by pCPA, the inhibitor of 5-HT synthesis, the effect of SP 
      on elevating pain threshold and the 5-HT contents of hypothalamus, hippocampus 
      were markedly attenuated, bud did not prevent the analgesic effect of SP (2) The 
      pain threshold and the 5-HT contents of hypothalamus, hippocampus were 
      dose-dependently increased by intra-PAG injection of SP. (3) The intra-PAG 
      injection of SP introduced simultaneously with high or low frequency EA did not 
      affect the change of 5-HT contents of three brain regions, but caused a more 
      marked elevation of pain threshold. These results suggest that the serotoninergic 
      system may be activated by PAG for the mediation of SP induced analgesia. There 
      is a synergic action of analgesia between the effects produced by intra-PAG 
      injection of SP and those by high or low frequency EA.
FAU - Li, X
AU  - Li X
AD  - Department of Physiology, Third Military Medical College, Chongqing.
FAU - Zhao, B
AU  - Zhao B
FAU - Ruan, H
AU  - Ruan H
FAU - Li, H
AU  - Li H
FAU - Liu, Z
AU  - Liu Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhen Ci Yan Jiu
JT  - Zhen ci yan jiu = Acupuncture research
JID - 8507710
RN  - 333DO1RDJY (Serotonin)
RN  - 33507-63-0 (Substance P)
SB  - IM
MH  - *Acupuncture Analgesia
MH  - Animals
MH  - Brain/*metabolism
MH  - *Electroacupuncture
MH  - Female
MH  - Injections, Intraventricular
MH  - Male
MH  - Microinjections
MH  - Pain/*physiopathology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sensory Thresholds
MH  - Serotonin/*metabolism
MH  - Substance P/*pharmacology
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
PST - ppublish
SO  - Zhen Ci Yan Jiu. 1991;16(2):125-8.