PMID- 17172857
OWN - NLM
STAT- MEDLINE
DCOM- 20070125
LR  - 20200930
IS  - 1551-4005 (Electronic)
IS  - 1551-4005 (Linking)
VI  - 5
IP  - 23
DP  - 2006 Dec
TI  - Degradation of the hypoxia-inducible factor 1alpha: where does it happen?
PG  - 2720-2
AB  - Adaptive responses to hypoxia are essential for the survival of all organisms. 
      Under hypoxic conditions, transcription of a large group of genes relevant for 
      oxygen homeostasis is induced by the hypoxia-inducible factor-1 (HIF-1). These 
      genes encode proteins that enable the cells to adapt to limiting oxygen levels by 
      increasing oxygen delivery through induction of angiogenesis or erythropoiesis 
      and producing ATP under anaerobic conditions. The stability of HIF-1alpha protein 
      is also target of O2 regulation. At normoxia HIF-1alpha is hydroxylated at 
      specific proline residues by a recently identified family of prolyl hydroxylases. 
      Hydroxylated HIF-1alpha is recognized by the Von Hippel-Lindau tumor suppressor 
      gene product (pVHL) as an ubiquitylation substrate that leads to 
      proteasomal-dependent degradation of HIF-1alpha. We have recently demonstrated 
      that the major subcellular compartment where degradation of HIF-1alpha occurs is 
      dependent on the levels of proteasomal activity and on the localization of 
      HIF-1alpha. Furthermore we have shown that the localization of HIF-1alpha 
      degradation is a cell type-characteristic parameter. These observations indicate 
      new levels of complexity in the regulation of HIF-1alpha degradation.
FAU - Pereira, Teresa
AU  - Pereira T
AD  - Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, 
      Sweden. Teresa.Pereira@ki.se
FAU - Zheng, Xiaowei
AU  - Zheng X
FAU - Poellinger, Lorenz
AU  - Poellinger L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061201
PL  - United States
TA  - Cell Cycle
JT  - Cell cycle (Georgetown, Tex.)
JID - 101137841
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - EC 2.3.2.27 (Von Hippel-Lindau Tumor Suppressor Protein)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
MH  - Mice
MH  - *Protein Processing, Post-Translational
MH  - Protein Transport
MH  - Von Hippel-Lindau Tumor Suppressor Protein/metabolism
EDAT- 2006/12/19 09:00
MHDA- 2007/01/26 09:00
CRDT- 2006/12/19 09:00
PHST- 2006/12/19 09:00 [pubmed]
PHST- 2007/01/26 09:00 [medline]
PHST- 2006/12/19 09:00 [entrez]
AID - 3536 [pii]
AID - 10.4161/cc.5.23.3536 [doi]
PST - ppublish
SO  - Cell Cycle. 2006 Dec;5(23):2720-2. doi: 10.4161/cc.5.23.3536. Epub 2006 Dec 1.