PMID- 17173107
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20240315
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 3
IP  - 4
DP  - 2006 Dec
TI  - The use of herbal medicine in Alzheimer's disease-a systematic review.
PG  - 441-5
AB  - The treatments of choice in Alzheimer's disease (AD) are cholinesterase 
      inhibitors and NMDA-receptor antagonists, although doubts remain about the 
      therapeutic effectiveness of these drugs. Herbal medicine products have been used 
      in the treatment of Behavioral and Psychological Symptoms of Dementia (BPSD) but 
      with various responses. The objective of this article was to review evidences 
      from controlled studies in order to determine whether herbs can be useful in the 
      treatment of cognitive disorders in the elderly. Randomized controlled studies 
      assessing AD in individuals older than 65 years were identified through searches 
      of MEDLINE, LILACS, Cochrane Library, dissertation Abstract (USA), ADEAR 
      (Alzheimer's Disease Clinical Trials Database), National Research Register, 
      Current Controlled trials, Centerwatch Trials Database and PsychINFO Journal 
      Articles. The search combined the terms Alzheimer disease, dementia, cognition 
      disorders, Herbal, Phytotherapy. The crossover results were evaluated by the 
      Jadad's measurement scale. The systematic review identified two herbs and herbal 
      formulations with therapeutic effects for the treatment of AD: Melissa 
      officinalis, Salvia officinalis and Yi-Gan San and BDW (Ba Wei Di Huang Wan). 
      Ginkgo biloba was identified in a meta-analysis study. All five herbs are useful 
      for cognitive impairment of AD. M. officinalis and Yi-Gan San are also useful in 
      agitation, for they have sedative effects. These herbs and formulations have 
      demonstrated good therapeutic effectiveness but these results need to be compared 
      with those of traditional drugs. Further large multicenter studies should be 
      conducted in order to test the cost-effectiveness of these herbs for AD and the 
      impact in the control of cognitive deterioration.
FAU - Dos Santos-Neto, Leopoldo Luiz
AU  - Dos Santos-Neto LL
FAU - de Vilhena Toledo, Maria Alice
AU  - de Vilhena Toledo MA
FAU - Medeiros-Souza, Patricia
AU  - Medeiros-Souza P
FAU - de Souza, Gustavo Almeida
AU  - de Souza GA
LA  - eng
PT  - Journal Article
DEP - 20061023
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC1697739
EDAT- 2006/12/19 09:00
MHDA- 2006/12/19 09:01
PMCR- 2006/12/01
CRDT- 2006/12/19 09:00
PHST- 2005/11/26 00:00 [received]
PHST- 2006/09/15 00:00 [accepted]
PHST- 2006/12/19 09:00 [pubmed]
PHST- 2006/12/19 09:01 [medline]
PHST- 2006/12/19 09:00 [entrez]
PHST- 2006/12/01 00:00 [pmc-release]
AID - 10.1093/ecam/nel071 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2006 Dec;3(4):441-5. doi: 
      10.1093/ecam/nel071. Epub 2006 Oct 23.