PMID- 17173638
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20070716
LR  - 20220408
IS  - 1467-7652 (Electronic)
IS  - 1467-7644 (Linking)
VI  - 3
IP  - 5
DP  - 2005 Sep
TI  - Oral immunotherapy against a pollen allergy using a seed-based peptide vaccine.
PG  - 521-33
AB  - Peptide immunotherapy using dominant T-cell epitopes is safer and more effective 
      than conventional immunotherapy for the treatment of immunoglobulin E 
      (IgE)-mediated allergic diseases. When allergenic T-cell epitope peptides are 
      expressed in the edible part of transgenic plants, successful mucosal immune 
      tolerance to these allergens may be attainable by the consumption of these 
      plants. In this study, we generated transgenic rice seed that accumulated high 
      concentrations (about 60 microg per grain) of polypeptide consisting of seven 
      dominant human T-cell epitopes derived from the Japanese cedar pollen allergens, 
      Cry j 1 and Cry j 2, in the endosperm. Oral administration of these transgenic 
      rice seeds to B10.S mice before or after they were immunized with Cry j 1 
      holoprotein reduced not only their T-cell proliferative response to Cry j 1, but 
      also their serum IgE levels, proving the efficacy of oral immunotherapy for the 
      treatment of pollinosis.
FAU - Takagi, Hidenori
AU  - Takagi H
AD  - Department of Plant Biotechnology, National Institute of Agrobiological Sciences, 
      Kannondai 2-1-2, Tsukuba 305-8602, Japan.
FAU - Saito, Saburo
AU  - Saito S
FAU - Yang, Lijun
AU  - Yang L
FAU - Nagasaka, Seiji
AU  - Nagasaka S
FAU - Nishizawa, Naoko
AU  - Nishizawa N
FAU - Takaiwa, Fumio
AU  - Takaiwa F
LA  - eng
PT  - Journal Article
PL  - England
TA  - Plant Biotechnol J
JT  - Plant biotechnology journal
JID - 101201889
EDAT- 2006/12/19 09:00
MHDA- 2006/12/19 09:01
CRDT- 2006/12/19 09:00
PHST- 2006/12/19 09:00 [pubmed]
PHST- 2006/12/19 09:01 [medline]
PHST- 2006/12/19 09:00 [entrez]
AID - PBI143 [pii]
AID - 10.1111/j.1467-7652.2005.00143.x [doi]
PST - ppublish
SO  - Plant Biotechnol J. 2005 Sep;3(5):521-33. doi: 10.1111/j.1467-7652.2005.00143.x.