PMID- 17173660
OWN - NLM
STAT- MEDLINE
DCOM- 20070320
LR  - 20230124
IS  - 1600-6135 (Print)
IS  - 1600-6135 (Linking)
VI  - 7
IP  - 2
DP  - 2007 Feb
TI  - Simple measures to monitor beta-cell mass and assess islet graft dysfunction.
PG  - 303-8
AB  - The aim of this study was to develop a simple test for the assessment of islet 
      graft dysfunction based on measures involving fasting C-peptide. Calculations 
      were made to account for the dependence of C-peptide secretion on glucose 
      concentration (C-peptide/glucose ratio [CP/G]) and adjusted for renal function by 
      calculating the C-peptide/glucose-creatinine ratio (CP/GCr). Values from 22 
      recipients were analyzed at different times post-last islet infusion. Receiver 
      operating characteristic curves were used to determine which of these measures 
      best predicts high 90-minute glucose (90 min-Glc; >10 mmol/L) after a Mixed Meal 
      Tolerance Test (MMTT). In this initial analysis, CP/G was found to be superior 
      predicting high 90 min-Glc with a larger area under the ROC curve than C-peptide 
      (p = 0.01) and CP/GCr (p = 0.06). We then correlated C-peptide and CP/G with 
      islet equivalents--IEQ/kg infused, 90 min-Glc after MMTT and clinical outcome 
      (beta-score). C-peptide and CP/G in the first 3 months post-last islet infusion 
      correlated with IEQ/kg infused. CP/G correlated with 90 min-Glc and beta-score. 
      C-peptide and CP/G are good indicators of islet mass transplanted. CP/G is more 
      indicative of graft dysfunction and clinical outcome than C-peptide alone. The 
      ease of calculation and the good correlation with other tests makes this ratio a 
      practical tool when monitoring and managing islet transplant recipients.
FAU - Faradji, R N
AU  - Faradji RN
AD  - Clinical Islet Transplant Program at the Diabetes Research Institute, University 
      of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States.
FAU - Monroy, K
AU  - Monroy K
FAU - Messinger, S
AU  - Messinger S
FAU - Pileggi, A
AU  - Pileggi A
FAU - Froud, T
AU  - Froud T
FAU - Baidal, D A
AU  - Baidal DA
FAU - Cure, P E
AU  - Cure PE
FAU - Ricordi, C
AU  - Ricordi C
FAU - Luzi, L
AU  - Luzi L
FAU - Alejandro, R
AU  - Alejandro R
LA  - eng
GR  - M01RR16587/RR/NCRR NIH HHS/United States
GR  - R01 DK52802/DK/NIDDK NIH HHS/United States
GR  - U24RR016603/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20061206
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - C-Peptide/*blood
MH  - Creatinine/blood
MH  - Female
MH  - Graft Rejection/*blood/diagnosis/*physiopathology
MH  - Humans
MH  - Insulin-Secreting Cells/*pathology
MH  - Islets of Langerhans Transplantation/pathology/*physiology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2006/12/19 09:00
MHDA- 2007/03/21 09:00
CRDT- 2006/12/19 09:00
PHST- 2006/12/19 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2006/12/19 09:00 [entrez]
AID - S1600-6135(22)14576-4 [pii]
AID - 10.1111/j.1600-6143.2006.01620.x [doi]
PST - ppublish
SO  - Am J Transplant. 2007 Feb;7(2):303-8. doi: 10.1111/j.1600-6143.2006.01620.x. Epub 
      2006 Dec 6.