PMID- 17174385
OWN - NLM
STAT- MEDLINE
DCOM- 20070312
LR  - 20171116
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 85
IP  - 3
DP  - 2006 Nov
TI  - Effect of the flavonoid, oroxylin A, on transient cerebral hypoperfusion-induced 
      memory impairment in mice.
PG  - 658-68
AB  - Oroxylin A is a flavonoid compound that is found in the root of Scutellaria 
      baicalensis Georgi. The aim of this study was to determine the effects of 
      oroxylin A on memory impairment induced by transient bilateral common carotid 
      artery occlusion (2VO) in mice. The ameliorating effect of oroxylin A on memory 
      impairment was investigated using a passive avoidance task, the Y-maze task, and 
      the Morris water maze task in mice. Oroxylin A was found to significantly reverse 
      2VO-induced cognitive impairments in the passive avoidance and Y-maze tasks in a 
      dose dependant manner (P<0.05). Moreover, oroxylin A (5 mg/kg, p.o.) shortened 
      the escape-latency and prolonged swimming times in the target quadrant during the 
      probe trial in the Morris water maze task (P<0.05). Histochemical and 
      immunohistochemical studies showed that the number of Nissl bodies and OX-42 
      positive cells in the hippocampal CA1 and dentate gyrus regions were attenuated 
      by oroxylin A. Moreover, phosphorylated cAMP response element-binding protein 
      (CREB) and brain derived neurotrophic factor (BDNF) positive cell numbers were 
      markedly increased in animals treated with oroxylin A than in untreated 2VO 
      controls. These results suggest that oroxylin A dramatically attenuates the 
      memory impairment induced by 2VO, and that this effect may be mediated by the 
      neuroprotective effects of oroxylin A as supported oroxylin A induced reductions 
      in activated microglia and increases in BDNF expression and CREB phosphorylation.
FAU - Kim, Dong Hyun
AU  - Kim DH
AD  - Department of Oriental Pharmaceutical Science and Kyung Hee East-West 
      Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, #1 
      Hoeki-dong, Dongdeamoon-ku, Seoul 130-701, Republic of Korea.
FAU - Jeon, Su Jin
AU  - Jeon SJ
FAU - Son, Kun Ho
AU  - Son KH
FAU - Jung, Ji Wook
AU  - Jung JW
FAU - Lee, Seungjoo
AU  - Lee S
FAU - Yoon, Byung Hoon
AU  - Yoon BH
FAU - Choi, Ji Woong
AU  - Choi JW
FAU - Cheong, Jae Hoon
AU  - Cheong JH
FAU - Ko, Kwang Ho
AU  - Ko KH
FAU - Ryu, Jong Hoon
AU  - Ryu JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061214
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Benzoxazines)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Flavonoids)
RN  - 0 (Oxazines)
RN  - 2AB49C465R (cresyl violet)
RN  - 53K24Z586G (5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Benzoxazines
MH  - Brain-Derived Neurotrophic Factor/analysis
MH  - Carotid Artery, Common
MH  - Carotid Stenosis/complications
MH  - Cyclic AMP/physiology
MH  - Dose-Response Relationship, Drug
MH  - Flavonoids/*therapeutic use
MH  - Immunohistochemistry
MH  - Ischemic Attack, Transient/*complications
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*drug therapy
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Oxazines
EDAT- 2006/12/19 09:00
MHDA- 2007/03/14 09:00
CRDT- 2006/12/19 09:00
PHST- 2006/06/23 00:00 [received]
PHST- 2006/10/26 00:00 [revised]
PHST- 2006/10/30 00:00 [accepted]
PHST- 2006/12/19 09:00 [pubmed]
PHST- 2007/03/14 09:00 [medline]
PHST- 2006/12/19 09:00 [entrez]
AID - S0091-3057(06)00357-1 [pii]
AID - 10.1016/j.pbb.2006.10.025 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2006 Nov;85(3):658-68. doi: 10.1016/j.pbb.2006.10.025. 
      Epub 2006 Dec 14.