PMID- 17174420
OWN - NLM
STAT- MEDLINE
DCOM- 20070816
LR  - 20161124
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 120
IP  - 2
DP  - 2007 Aug 21
TI  - Prevalance of anemia and its association with cardio-renal syndrome.
PG  - 232-6
AB  - BACKGROUND: Anemia is common in cardio-renal syndrome and may contribute to 
      increase mortality. OBJECTIVE: To examine the prevalence of anemia and its 
      relationship with cardio-renal syndrome, and to evaluate the risk factors for 
      death. METHODS: Retrospective study with all patients admitted with congestive 
      heart failure (CHF). The parameters as age, gender, hemoglobin (Hb), estimated 
      glomerular filtration rate (eGFR), New York Heart Association (NYHA) functional 
      class, ejection fraction (EF%), hospital stay, hypertension, diabetes, smoking 
      and CHF etiology were analyzed. Anemia was defined as Hb<12 g/dL, systolic 
      dysfunction EF<55% and renal failure was stratified according to K-DOQI 
      classification. Statistical analysis was done by the programs EpiInfo and SPSS 
      for windows. RESULTS: A total of 174 patients were studied. The average age was 
      63+/-16 years, 65.5% were males, and 18 of them (11%) were non-survivors. Anemia 
      was observed in 45% of patients, and 82% presented some degree of renal failure. 
      The majority of patients (87%) were classified as NYHA functional class III or 
      IV. The average ejection fraction was 43.9+/-16.6%, and there was no difference 
      between survivors and non-survivors (p>0.05). Mortality was not significantly 
      higher among patients with anemia (12.4%) when comparing to those without anemia 
      (8.3%, p=0.31). There was a progressive decrease in the level of hemoglobin as 
      renal function decreased (p<0.05). Increased serum creatinine was a significant 
      risk factor for death (OR=1.59, 95% CI=1.074-2.363, p=0.021), and increased EF% 
      was a protection factor against development of death (OR=0.904, 95% 
      CI=0.845-0.973, p=0.007). CONCLUSIONS: The prevalence of anemia is high among 
      patients with cardio-renal syndrome but was not associated with increased 
      mortality. Increased serum creatinine and low EF% were variables associated with 
      death.
FAU - Silva, Ricardo P
AU  - Silva RP
AD  - Division of Cardiology, Hospital Universitario Walter Cantidio, Departamento de 
      Medicina Clinica, Faculdade de Medicina, Universidade Federal do Ceara, 
      Fortaleza, Ceara, Brazil. ricardops@secrel.com.br
FAU - Barbosa, Paulo H U
AU  - Barbosa PH
FAU - Kimura, Osamu S
AU  - Kimura OS
FAU - Sobrinho, Carlos Roberto M R
AU  - Sobrinho CR
FAU - Sousa Neto, Joao David
AU  - Sousa Neto JD
FAU - Silva, Frederico A L
AU  - Silva FA
FAU - Silva Junior, Geraldo B
AU  - Silva Junior GB
FAU - Mota, Rosa M S
AU  - Mota RM
FAU - Daher, Elizabeth F
AU  - Daher EF
LA  - eng
PT  - Journal Article
DEP - 20061215
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Hemoglobins)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
CIN - Int J Cardiol. 2008 Aug 18;128(2):255-6. PMID: 17559955
MH  - Aged
MH  - Anemia/blood/*epidemiology/etiology
MH  - Brazil/epidemiology
MH  - Creatinine/metabolism
MH  - Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerular Filtration Rate
MH  - Heart Failure/*complications/diagnostic imaging/physiopathology
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Kidney Failure, Chronic/*complications/metabolism/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Stroke Volume
MH  - Syndrome
EDAT- 2006/12/19 09:00
MHDA- 2007/08/19 09:00
CRDT- 2006/12/19 09:00
PHST- 2006/05/28 00:00 [received]
PHST- 2006/08/15 00:00 [revised]
PHST- 2006/10/01 00:00 [accepted]
PHST- 2006/12/19 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2006/12/19 09:00 [entrez]
AID - S0167-5273(06)01354-4 [pii]
AID - 10.1016/j.ijcard.2006.10.005 [doi]
PST - ppublish
SO  - Int J Cardiol. 2007 Aug 21;120(2):232-6. doi: 10.1016/j.ijcard.2006.10.005. Epub 
      2006 Dec 15.