PMID- 17175386
OWN - NLM
STAT- MEDLINE
DCOM- 20070125
LR  - 20061218
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 172
IP  - 1
DP  - 2007 Jan 1
TI  - Tiling resolution array comparative genomic hybridization analysis of a 
      fibrosarcoma of bone.
PG  - 80-3
AB  - Fibrosarcoma of bone is a rare malignant tumor accounting for less than 5% of all 
      primary malignant bone neoplasms. There is very limited knowledge regarding the 
      molecular genetics of this tumor, and there are no cytogenetic data available. In 
      the present study, a fibrosarcoma deriving from the left iliac bone of a 
      10-year-old girl was characterized using cytogenetics, fluorescence in situ 
      hybridization (FISH), and whole genome tiling resolution array comparative 
      genomic hybridization (CGH). Cytogenetic and FISH analyses revealed a ring 
      chromosome 6 as the sole acquired aberration, a finding corroborated by array 
      CGH. The ring formation, however, did not result in any gain of genetic material. 
      Nor did the breakpoints in 6p25 and 6q14 seem to affect any known gene loci in 
      such a way that the ring formation could have resulted in the creation of a 
      fusion gene or in the exchange of regulatory sequences. Thus, a reasonable 
      interpretation of the pathogenetic significance of the ring formation would be 
      that it resulted in the loss of one or more putative tumor suppressor gene loci 
      distal to the two breakpoints.
FAU - Hallor, Karolin H
AU  - Hallor KH
AD  - Department of Clinical Genetics, Lund University Hospital, SE-221 85 Lund, 
      Sweden. Karolin.Hansen_Hallor@med.lu.se <Karolin.Hansen_Hallor@med.lu.se>
FAU - Heidenblad, Markus
AU  - Heidenblad M
FAU - Brosjo, Otte
AU  - Brosjo O
FAU - Mandahl, Nils
AU  - Mandahl N
FAU - Mertens, Fredrik
AU  - Mertens F
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Bone Neoplasms/diagnosis/*genetics
MH  - Child
MH  - Chromosomes, Human, Pair 6/*genetics
MH  - Female
MH  - Fibrosarcoma/diagnosis/*genetics
MH  - Humans
MH  - Ilium/pathology
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Magnetic Resonance Imaging
MH  - Nucleic Acid Hybridization
MH  - *Ring Chromosomes
EDAT- 2006/12/19 09:00
MHDA- 2007/01/26 09:00
CRDT- 2006/12/19 09:00
PHST- 2006/07/06 00:00 [received]
PHST- 2006/08/28 00:00 [revised]
PHST- 2006/08/31 00:00 [accepted]
PHST- 2006/12/19 09:00 [pubmed]
PHST- 2007/01/26 09:00 [medline]
PHST- 2006/12/19 09:00 [entrez]
AID - S0165-4608(06)00561-9 [pii]
AID - 10.1016/j.cancergencyto.2006.08.007 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2007 Jan 1;172(1):80-3. doi: 
      10.1016/j.cancergencyto.2006.08.007.