PMID- 17176444
OWN - NLM
STAT- MEDLINE
DCOM- 20070508
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 68
IP  - 6
DP  - 2006 Dec
TI  - Association of the maternal 14-bp insertion polymorphism in the HLA-G gene in 
      women with recurrent spontaneous abortions.
PG  - 521-3
AB  - Human leukocyte antigen (HLA)-G has been postulated as an important 
      immunotolerant molecule in maintaining fetal-maternal relationship. Recent 
      reports indicated that the 14-bp deletion/insertion polymorphism in exon 8 of 
      HLA-G gene influences HLA-G mRNA stability and isoform splicing patterns, thus 
      modulating the levels of HLA-G expression. This might play an immunomodulatory 
      role of HLA-G during implantation and pregnancy. In the present study, 109 
      unrelated fertile control women and 79 women who had experienced recurrent 
      spontaneous abortion (RSA) were genotyped for the 14-bp insertion/deletion 
      polymorphism. No significant difference was observed in the distribution of 14-bp 
      insertion/deletion genotype between controls and the RSA group. However, a 
      greater number of 14-bp insertion alleles exist in the RSA group than in the 
      controls.
FAU - Yan, W H
AU  - Yan WH
AD  - Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical 
      College, Linhai, Zhejiang, People's Republic of China. yanwhcom@yahoo.com
FAU - Lin, A
AU  - Lin A
FAU - Chen, X J
AU  - Chen XJ
FAU - Dai, M Z
AU  - Dai MZ
FAU - Gan, L H
AU  - Gan LH
FAU - Zhou, M Y
AU  - Zhou MY
FAU - Zhu, M
AU  - Zhu M
FAU - Shi, W W
AU  - Shi WW
FAU - Liu, J M
AU  - Liu JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Abortion, Habitual/diagnosis/*genetics/immunology
MH  - Alleles
MH  - Female
MH  - Genotype
MH  - HLA Antigens/analysis/*genetics
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/analysis/*genetics
MH  - Humans
MH  - *Polymorphism, Genetic
MH  - Pregnancy
MH  - RNA Stability
MH  - RNA, Messenger/metabolism
EDAT- 2006/12/21 09:00
MHDA- 2007/05/09 09:00
CRDT- 2006/12/21 09:00
PHST- 2006/12/21 09:00 [pubmed]
PHST- 2007/05/09 09:00 [medline]
PHST- 2006/12/21 09:00 [entrez]
AID - TAN723 [pii]
AID - 10.1111/j.1399-0039.2006.00723.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2006 Dec;68(6):521-3. doi: 10.1111/j.1399-0039.2006.00723.x.