PMID- 17177701
OWN - NLM
STAT- MEDLINE
DCOM- 20070320
LR  - 20061220
IS  - 0105-1873 (Print)
IS  - 0105-1873 (Linking)
VI  - 56
IP  - 1
DP  - 2007 Jan
TI  - Information derived from sensitization test methods: test sensitivity, false 
      positives and false negatives.
PG  - 1-4
AB  - Predictive toxicology tests for the prospective identification of 
      skin-sensitizing chemicals are well known and have been used for many years. 
      However, of these, only the local lymph node assay (LLNA) has actually undergone 
      formal independent assessment to determine the accuracy of the predictions, 
      particularly with respect to the likelihood of false positives and false 
      negatives. Often, efforts to increase the sensitivity of a test (reducing false 
      negatives) tend to increase the number of false positives. In this short review, 
      these issues are discussed in particular relation to the 3 predictive tests 
      available in regulatory toxicology, the guinea-pig maximization test, the 
      occluded patch test of Buehler and the LLNA. A key perspective is that no 
      predictive test is without limitations; having a good appreciation of these 
      limitations is necessary for making the best use of the information derived from 
      these methods.
FAU - Basketter, David A
AU  - Basketter DA
AD  - Safety and Environmental Assurance Centre, Unilever, Bedford, UK. 
      david.basketter@unilever.com
FAU - Kimber, Ian
AU  - Kimber I
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Contact Dermatitis
JT  - Contact dermatitis
JID - 7604950
SB  - IM
MH  - Animals
MH  - Dermatitis, Contact
MH  - False Negative Reactions
MH  - False Positive Reactions
MH  - Guinea Pigs
MH  - Humans
MH  - Sensitivity and Specificity
MH  - Skin Tests/*standards
MH  - Toxicity Tests/*standards
RF  - 42
EDAT- 2006/12/21 09:00
MHDA- 2007/03/21 09:00
CRDT- 2006/12/21 09:00
PHST- 2006/12/21 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2006/12/21 09:00 [entrez]
AID - COD1009 [pii]
AID - 10.1111/j.1600-0536.2007.01009.x [doi]
PST - ppublish
SO  - Contact Dermatitis. 2007 Jan;56(1):1-4. doi: 10.1111/j.1600-0536.2007.01009.x.