PMID- 17177969
OWN - NLM
STAT- MEDLINE
DCOM- 20070329
LR  - 20220321
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 147
IP  - 1
DP  - 2007 Jan
TI  - The involvement of Fc gamma receptor gene polymorphisms in Kawasaki disease.
PG  - 106-11
AB  - Kawasaki disease is an acute febrile syndrome in infancy, characterized by 
      vasculitis of medium-sized arteries. Without treatment the disease can lead to 
      coronary artery lesions (CAL) in approximately 25% of the children. Therapy 
      consists of intravenous immunoglobulins (IVIG), leading to a decrease of 
      complications to 5-16%. Little is known about the working mechanisms of IVIG. In 
      this study we evaluated the involvement of Fcgamma receptors (FcgammaRs) in 
      Kawasaki disease by the determination of the frequency of known single nucleotide 
      polymorphisms (SNPs) in the genes coding for the FcgammaRs and compared this with 
      frequencies in a cohort of healthy controls. There was no difference in the 
      distribution of the functionally relevant genotypes for FcgammaRIIa-131H/R, 
      FcgammaRIIb-232I/T, FcgammaRIIIa-158 V/F and FcgammaRIIIb-NA1/NA2 between the 
      patient group and the healthy controls. Furthermore, there were no polymorphisms 
      linked to the disease severity as indicated by the absence or development of CAL 
      during the disease. Altered transcription or expression of FcgammaR on specific 
      cell types of the immune system may still play a role in susceptibility and 
      treatment success, but at a level different from the functional SNPs in FcgammaR 
      genes tested in this study.
FAU - Biezeveld, M
AU  - Biezeveld M
AD  - Emma Children's Hospital, Academic Medical Centre (AMC), University of Amsterdam, 
      Amsterdam, The Netherlands. m.h.biezeveld@amc.uva.nl
FAU - Geissler, J
AU  - Geissler J
FAU - Merkus, M
AU  - Merkus M
FAU - Kuipers, I M
AU  - Kuipers IM
FAU - Ottenkamp, J
AU  - Ottenkamp J
FAU - Kuijpers, T
AU  - Kuijpers T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Genetic Markers)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Coronary Disease/complications/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Markers
MH  - Genotype
MH  - Humans
MH  - Immunoglobulins, Intravenous
MH  - Logistic Models
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/complications/*genetics/therapy
MH  - Multivariate Analysis
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, IgG/*genetics
MH  - Risk Factors
PMC - PMC1810456
EDAT- 2006/12/21 09:00
MHDA- 2007/03/30 09:00
PMCR- 2008/01/01
CRDT- 2006/12/21 09:00
PHST- 2006/12/21 09:00 [pubmed]
PHST- 2007/03/30 09:00 [medline]
PHST- 2006/12/21 09:00 [entrez]
PHST- 2008/01/01 00:00 [pmc-release]
AID - CEI3266 [pii]
AID - 10.1111/j.1365-2249.2006.03266.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2007 Jan;147(1):106-11. doi: 10.1111/j.1365-2249.2006.03266.x.