PMID- 17178032
OWN - NLM
STAT- MEDLINE
DCOM- 20070220
LR  - 20061220
IS  - 1008-8830 (Print)
IS  - 1008-8830 (Linking)
VI  - 8
IP  - 6
DP  - 2006 Dec
TI  - [Gene mutation of high affinity immunoglobulin E receptor beta-chain in children 
      with asthma].
PG  - 453-6
AB  - OBJECTIVE: To investigate the association of the polymorphism of I181L, V183L and 
      E237G in the high affinity immunoglobulin E receptor beta-chain (FcepsilonR1beta) 
      with the susceptibility of childhood asthma and the serum total immunoglobulin E 
      (IgE) level. METHODS: The coding variants of I181L, V183L and E237G and the serum 
      total IgE level were detected using amplification refractory mutation 
      systemdouble ended arrowpolymerase chain reaction (ARMS-PCR) and double antibody 
      sandwich ELISA respectively in 50 asthmatic children and 40 normal controls from 
      Sichuan Province. The association of gene mutation with the susceptibility of 
      asthma and the serum total IgE level was analyzed. RESULTS: There were 5 cases of 
      I181L mutation, 2 of V183L mutation, and 7 of E237G mutation in the Asthmatic 
      group. There was no mutation in the Normal control group. The frequency of I181L 
      and E237G mutation in the Asthmatic group were statistically higher than in the 
      Normal control group (P < 0.01). The serum total IgE level in the Asthmatic 
      subgroup with I181L mutation (2.837 +/- 0.407) or E237G mutation (3.044 +/- 
      0.419) was significantly higher than in the Asthmatic subgroup without gene 
      mutation (2.156 +/- 0.638) and the Normal control group (1.348 +/- 1.291) (P < 
      0.05 or 0.01). CONCLUSIONS: The polymorphism of Fc epsilonR1betaI181L and E237G 
      is a susceptible gene of childhood asthma and closely associates with the 
      increased serum total IgE level.
FAU - Li, Min
AU  - Li M
AD  - Department of Pediatrics, Sichuan Province People's Hospital, Chengdu 610072, 
      China. Lmscsy@yahoo.com.cn
FAU - Du, Qiong
AU  - Du Q
FAU - Li, Lan
AU  - Li L
FAU - Song, Li
AU  - Song L
FAU - Li, Bo
AU  - Li B
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Dang Dai Er Ke Za Zhi
JT  - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
JID - 100909956
RN  - 0 (MS4A2 protein, human)
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Asthma/*genetics/immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Male
MH  - *Mutation
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Receptors, IgE/*genetics
EDAT- 2006/12/21 09:00
MHDA- 2007/02/21 09:00
CRDT- 2006/12/21 09:00
PHST- 2006/12/21 09:00 [pubmed]
PHST- 2007/02/21 09:00 [medline]
PHST- 2006/12/21 09:00 [entrez]
AID - 1008-8830(2006)06-0453-04 [pii]
PST - ppublish
SO  - Zhongguo Dang Dai Er Ke Za Zhi. 2006 Dec;8(6):453-6.