PMID- 1717869
OWN - NLM
STAT- MEDLINE
DCOM- 19911104
LR  - 20181130
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 54
IP  - 1
DP  - 1991 Jul
TI  - Cholinergic modulation of growth hormone secretion induced by galanin in rats.
PG  - 83-8
AB  - The effects of cholinergic modulation by hexamethonium (HEX), tetraethylammonium 
      (TEA), pirenzepine (PIR) and neostigmine on growth hormone (GH) secretion induced 
      by galanin (GAL) were investigated in awake, freely moving male rats. 
      Intracerebroventricular (i.c.v.) injection of GAL (0.6 nmol) caused a marked 
      increase in plasma GH levels. Pretreatment with HEX (3 or 15 mg/kg BW), TEA (15 
      mg/kg BW) or PIR (0.5 mg/kg BW) significantly reduced the GAL-induced GH 
      secretion. Pretreatment of animals with neostigmine (0.05 mg/kg BW) or with a 
      specific antisomatostatin antiserum (10 microliters of 1:10 diluted with saline, 
      i.c.v.) reversed the inhibition of GAL-induced GH secretion by HEX. These 
      findings suggest that both nicotinic and muscarinic cholinergic mechanisms 
      interact with the galanin-induced GH secretion by modulating hypothalamic 
      somatostatin release.
FAU - Tanoh, T
AU  - Tanoh T
AD  - Department of Internal Medicine, Kyoto University Faculty of Medicine, Japan.
FAU - Shimatsu, A
AU  - Shimatsu A
FAU - Murakami, Y
AU  - Murakami Y
FAU - Ishikawa, Y
AU  - Ishikawa Y
FAU - Yanaihara, N
AU  - Yanaihara N
FAU - Imura, H
AU  - Imura H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Hexamethonium Compounds)
RN  - 0 (Immune Sera)
RN  - 0 (Parasympatholytics)
RN  - 0 (Peptides)
RN  - 3982TWQ96G (Neostigmine)
RN  - 3C9PSP36Z2 (Hexamethonium)
RN  - 3G0285N20N (Pirenzepine)
RN  - 51110-01-1 (Somatostatin)
RN  - 88813-36-9 (Galanin)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Animals
MH  - Galanin
MH  - Growth Hormone/*metabolism
MH  - Hexamethonium
MH  - Hexamethonium Compounds/pharmacology
MH  - Immune Sera/physiology
MH  - Male
MH  - Neostigmine/pharmacology
MH  - Parasympathetic Nervous System/*physiology
MH  - Parasympatholytics/pharmacology
MH  - Peptides/*pharmacology
MH  - Pirenzepine/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Somatostatin/immunology
EDAT- 1991/07/01 00:00
MHDA- 1991/07/01 00:01
CRDT- 1991/07/01 00:00
PHST- 1991/07/01 00:00 [pubmed]
PHST- 1991/07/01 00:01 [medline]
PHST- 1991/07/01 00:00 [entrez]
AID - 10.1159/000125855 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1991 Jul;54(1):83-8. doi: 10.1159/000125855.