PMID- 17182696
OWN - NLM
STAT- MEDLINE
DCOM- 20070327
LR  - 20181113
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 81
IP  - 5
DP  - 2007 Mar
TI  - Dendritic cell-mediated trans-enhancement of human immunodeficiency virus type 1 
      infectivity is independent of DC-SIGN.
PG  - 2519-23
AB  - Dendritic cells (DCs) enhance human immunodeficiency virus type 1 (HIV-1) 
      infection of CD4(+) T lymphocytes in trans. The C-type lectin DC-SIGN, expressed 
      on DCs, binds to the HIV-1 envelope glycoprotein gp120 and confers upon some cell 
      lines the capacity to enhance trans-infection. Using a short hairpin RNA 
      approach, we demonstrate that DC-SIGN is not required for efficient 
      trans-enhancement by DCs. In addition, the DC-SIGN ligand mannan and an 
      anti-DC-SIGN antibody did not inhibit DC-mediated enhancement. HIV-1 particles 
      were internalized and were protected from protease treatment following binding to 
      DCs, but not from binding to DC-SIGN-expressing Raji cells. Thus, DC-SIGN is not 
      required for DC-mediated trans-enhancement of HIV infectivity.
FAU - Boggiano, Cesar
AU  - Boggiano C
AD  - Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New 
      York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.
FAU - Manel, Nicolas
AU  - Manel N
FAU - Littman, Dan R
AU  - Littman DR
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20061220
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (HIV Envelope Protein gp120)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Recombinant Proteins)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Base Sequence
MH  - Cell Adhesion Molecules/genetics/*physiology
MH  - DNA/genetics
MH  - Dendritic Cells/*immunology/*virology
MH  - Fetal Blood/cytology
MH  - Gene Expression
MH  - Green Fluorescent Proteins/genetics/metabolism
MH  - HIV Envelope Protein gp120/physiology
MH  - HIV Infections/immunology/virology
MH  - HIV-1/*immunology/*pathogenicity
MH  - Humans
MH  - In Vitro Techniques
MH  - Infant, Newborn
MH  - Lectins, C-Type/genetics/*physiology
MH  - Receptors, Cell Surface/genetics/*physiology
MH  - Recombinant Proteins/genetics/metabolism
PMC - PMC1865951
EDAT- 2006/12/22 09:00
MHDA- 2007/03/28 09:00
PMCR- 2007/07/01
CRDT- 2006/12/22 09:00
PHST- 2006/12/22 09:00 [pubmed]
PHST- 2007/03/28 09:00 [medline]
PHST- 2006/12/22 09:00 [entrez]
PHST- 2007/07/01 00:00 [pmc-release]
AID - JVI.01661-06 [pii]
AID - 1661-06 [pii]
AID - 10.1128/JVI.01661-06 [doi]
PST - ppublish
SO  - J Virol. 2007 Mar;81(5):2519-23. doi: 10.1128/JVI.01661-06. Epub 2006 Dec 20.