PMID- 17182961
OWN - NLM
STAT- MEDLINE
DCOM- 20070220
LR  - 20111117
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1085
DP  - 2006 Nov
TI  - HLA-DQA is associated with abdominal aortic aneurysms in the Belgian population.
PG  - 392-5
AB  - Chronic inflammation and autoimmunity likely contribute to the pathogenesis of 
      abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the 
      role of autoimmunity in the etiology of AAAs using a genetic association study 
      approach with human leukocyte antigen (HLA) polymorphisms (HLA-DQA1, -DQB1, -DRB1 
      and -DRB3-5 alleles) in 387 AAA cases and 426 controls. We observed an 
      association with the HLA-DQA1 locus among Belgian males, and found a significant 
      difference in the HLA-DQA1*0102 allele frequencies between AAA cases and 
      controls. In conclusion, this study showed potential evidence that the HLA-DQA1 
      locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a 
      role in the pathogenesis of AAAs.
FAU - Tromp, Gerard
AU  - Tromp G
AD  - Center for Molecular Medicine and Genetics, Wayne State University School of 
      Medicine, 3317 Gordon H. Scott Hall of Basic Medical Sciences, 540 E. Canfield 
      Ave., Detroit, MI 48201, USA.
FAU - Ogata, Toru
AU  - Ogata T
FAU - Gregoire, Lucie
AU  - Gregoire L
FAU - Goddard, Katrina A B
AU  - Goddard KA
FAU - Skunca, Magdalena
AU  - Skunca M
FAU - Lancaster, Wayne D
AU  - Lancaster WD
FAU - Parrado, Antonio R
AU  - Parrado AR
FAU - Lu, Qing
AU  - Lu Q
FAU - Shibamura, Hidenori
AU  - Shibamura H
FAU - Sakalihasan, Natzi
AU  - Sakalihasan N
FAU - Limet, Raymond
AU  - Limet R
FAU - Mackean, Gerald L
AU  - Mackean GL
FAU - Arthur, Claudette
AU  - Arthur C
FAU - Sueda, Taijiro
AU  - Sueda T
FAU - Kuivaniemi, Helena
AU  - Kuivaniemi H
LA  - eng
GR  - HG01577/HG/NHGRI NIH HHS/United States
GR  - HL064310/HL/NHLBI NIH HHS/United States
GR  - RR03655/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQA1 antigen)
SB  - IM
MH  - Alleles
MH  - Aortic Aneurysm, Abdominal/*genetics
MH  - Belgium
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - Humans
MH  - *Population
MH  - Risk Factors
EDAT- 2006/12/22 09:00
MHDA- 2007/02/21 09:00
CRDT- 2006/12/22 09:00
PHST- 2006/12/22 09:00 [pubmed]
PHST- 2007/02/21 09:00 [medline]
PHST- 2006/12/22 09:00 [entrez]
AID - 1085/1/392 [pii]
AID - 10.1196/annals.1383.045 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2006 Nov;1085:392-5. doi: 10.1196/annals.1383.045.