PMID- 1718345
OWN - NLM
STAT- MEDLINE
DCOM- 19911212
LR  - 20011113
IS  - 0889-2229 (Print)
IS  - 0889-2229 (Linking)
VI  - 7
IP  - 8
DP  - 1991 Aug
TI  - Predictive B- and T-cell linear epitopes in structural proteins of HTLV-I, 
      HTLV-II, and STLV-I.
PG  - 663-70
AB  - The primary amino acid sequences derived from the gag, pol, and env gene products 
      of human T-cell lymphotropic virus type I (HTLV-I) and type II (HTLV-II) and the 
      env protein of simian T-cell lymphotropic virus type I (STLV-I) were aligned and 
      computer algorithms were used to predict B- and T-cell epitopes. Structural B- 
      and T-cell motifs that showed amino acid sequence conservation of antigenic 
      determinants in HTLV-I, HTLV-II, and STLV-I, as well as different antigenic 
      determinants of HTLV-I and HTLV-II, were identified. Several of these B and T 
      epitopes have been shown experimentally to be immunodominant and two of the B 
      epitopes have been used for type-specific serology. These predictive epitopes 
      provide a guide to develop improved diagnostic assays and for the development of 
      potential subunit vaccines for HILV-I and HTLV-II.
FAU - Lal, R B
AU  - Lal RB
AD  - Retrovirus Diseases Branch, Centers for Disease Control, Atlanta, GA 30333.
FAU - Griffis, K P
AU  - Griffis KP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
RN  - 0 (Epitopes)
RN  - 0 (Gene Products, env)
RN  - 0 (Gene Products, gag)
RN  - 0 (Gene Products, pol)
RN  - 0 (Viral Structural Proteins)
SB  - IM
MH  - Algorithms
MH  - Amino Acid Sequence
MH  - B-Lymphocytes/immunology
MH  - Computer Simulation
MH  - Epitopes/*immunology
MH  - Gene Products, env/immunology
MH  - Gene Products, gag/immunology
MH  - Gene Products, pol/immunology
MH  - Human T-lymphotropic virus 1/*immunology
MH  - Human T-lymphotropic virus 2/*immunology
MH  - Lymphocytes/*immunology
MH  - Molecular Sequence Data
MH  - Sequence Alignment
MH  - Simian T-lymphotropic virus 1/*immunology
MH  - T-Lymphocytes/immunology
MH  - Viral Structural Proteins/*immunology
EDAT- 1991/08/01 00:00
MHDA- 1991/08/01 00:01
CRDT- 1991/08/01 00:00
PHST- 1991/08/01 00:00 [pubmed]
PHST- 1991/08/01 00:01 [medline]
PHST- 1991/08/01 00:00 [entrez]
AID - 10.1089/aid.1991.7.663 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 1991 Aug;7(8):663-70. doi: 10.1089/aid.1991.7.663.