PMID- 17184079
OWN - NLM
STAT- MEDLINE
DCOM- 20070118
LR  - 20070402
IS  - 0022-3085 (Print)
IS  - 0022-3085 (Linking)
VI  - 105
IP  - 6 Suppl
DP  - 2006 Dec
TI  - Primary disseminated leptomeningeal oligodendroglioma with 1p deletion. Case 
      report.
PG  - 465-9
AB  - The authors report the case of a 2-year-old boy with a primary, diffuse 
      leptomeningeal oligodendroglioma in which the deletion of chromosome arm lp was 
      identified by performing a fluorescence in situ hybridization (FISH) analysis. 
      This previously healthy child initially presented with malaise, anorexia, nausea, 
      vomiting, and macrocephaly. Imaging studies confirmed the presence of 
      hydrocephalus, and a ventriculoperitoneal shunt was placed. The postoperative 
      course was complicated by emesis, continued weight loss, and numerous seizurelike 
      episodes. A contrast-enhanced magnetic resonance imaging study performed 
      approximately 10 weeks postoperatively showed diffuse leptomeningeal thickening 
      and enhancement without evidence of an intraparenchymal mass lesion. A right 
      frontal lobe brain biopsy revealed a hypercellular proliferation of small 
      oligodendroglioma-like cells, which occupied the leptomeninges diffusely and 
      spared the underlying cortical gray matter. The tumor cells displayed prominent 
      perinuclear clearing and had evenly spaced, uniformly round nuclei. Occasional 
      mitotic figures were observed. Background vessels were thin and delicate, and 
      there was no evidence of necrosis. The tumor cells showed strong immunoreactivity 
      for S100 protein; the results of immunohistochemical staining were negative for 
      glial fibrillary acidic protein, vimentin, epithelial membrane antigen, NeuN, and 
      synaptophysin. The deletion of lp was demonstrated by FISH analysis; lq, 19p, and 
      19q were intact. This appears to be the first reported case of a primary diffuse 
      leptomeningeal oligodendroglioma in which a lp deletion was identified.
FAU - Bourne, T David
AU  - Bourne TD
AD  - Department of Pathology, Division of Neuropathology, University of Virginia 
      Health System, Charlottesville, Virginia 22908-0214, USA.
FAU - Mandell, James W
AU  - Mandell JW
FAU - Matsumoto, Julie A
AU  - Matsumoto JA
FAU - Jane, John A Jr
AU  - Jane JA Jr
FAU - Lopes, M Beatriz S
AU  - Lopes MB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Neurosurg
JT  - Journal of neurosurgery
JID - 0253357
SB  - IM
MH  - Biopsy
MH  - Child, Preschool
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 1
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Meningeal Neoplasms/*genetics/pathology/surgery
MH  - Oligodendroglioma/*genetics/pathology/surgery
EDAT- 2006/12/23 09:00
MHDA- 2007/01/19 09:00
CRDT- 2006/12/23 09:00
PHST- 2006/12/23 09:00 [pubmed]
PHST- 2007/01/19 09:00 [medline]
PHST- 2006/12/23 09:00 [entrez]
AID - 10.3171/ped.2006.105.6.465 [doi]
PST - ppublish
SO  - J Neurosurg. 2006 Dec;105(6 Suppl):465-9. doi: 10.3171/ped.2006.105.6.465.